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Weak to moderate cytoplasmic positivity which often showed a granular pattern was observed in most malignant cells. Several cases of hepatocellular carcinomas, colorectal, thyroid, urothelial and ovarian cancers were strongly stained. Many cases of malignant gliomas were negative.
This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]