Expression of USP48 in cancer - Summary - The Human Protein Atlas

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USP48

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	USP48
Gene description	Ubiquitin specific peptidase 48
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA030045 , HPA030046
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030045	HPA030046

GENE INFORMATION
Gene name	USP48 (HGNC Symbol)
Synonyms	FLJ11328, FLJ20103, FLJ23054, FLJ23277, MGC14879, USP31
Description	Ubiquitin specific peptidase 48 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.12
Chromosome location (bp)	21678298 - 21783606
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000090686 (version 83.38)
Entrez gene	84196
UniProt	Q86UV5 (UniProt - Evidence at protein level)
neXtProt	NX_Q86UV5
Antibodypedia	USP48 antibodies

PROTEIN BROWSER

USP48-001	USP48-002	USP48-006	USP48-009	USP48-010	USP48-011	USP48-013	USP48-014	USP48-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
USP48-001 ENSP00000309262 ENST00000308271	Q86UV5 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 48 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045121 [membrane raft] GO:0045211 [postsynaptic membrane] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	1035 aa 119 kDa	No	0
USP48-002 ENSP00000363864 ENST00000374732	A0A0A0MRS6 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 48 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0016579 [protein deubiquitination] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	521 aa 59.4 kDa	No	0
USP48-006 ENSP00000406256 ENST00000421625	Q86UV5 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 48 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	485 aa 56.2 kDa	No	0
USP48-009 ENSP00000431949 ENST00000529637	Q86UV5 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 48 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	1047 aa 120.5 kDa	No	0
USP48-010 ENSP00000435612 ENST00000532737	E9PJ87 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 48 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0016579 [protein deubiquitination] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	39 aa 4.6 kDa	No	0
USP48-011 ENSP00000434073 ENST00000527823	E9PRY5 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 48 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0016579 [protein deubiquitination] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	48 aa 5.5 kDa	No	0
USP48-013 ENSP00000431832 ENST00000526044	E9PJH5 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 48 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0016579 [protein deubiquitination] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	135 aa 15.8 kDa	No	0
USP48-014 ENSP00000435604 ENST00000534705	E9PJ93 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 48 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0016579 [protein deubiquitination] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	147 aa 17.2 kDa	No	0
USP48-201 ENSP00000383157 ENST00000400301	Q86UV5 [Direct mapping] Ubiquitin carboxyl-terminal hydrolase 48 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0061136 [regulation of proteasomal protein catabolic process] Show all	983 aa 113 kDa	No	0

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