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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AARS
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    TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AARS

Gene description

Alanyl-tRNA synthetase

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA040870 , CAB034261
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA040870
CAB034261

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignant tissues showed moderate cytoplasmic staining. Several prostate and breast cancers along with a few malignant melanoma, squamous cell carcinoma and colorectal cancers were strongly stained.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate cytoplasmic immunoreactivity was observed in most cancers. Several cases of ovarian and prostate cancers were strongly stained.

GENE INFORMATION

Gene name

AARS (HGNC Symbol)

Synonyms

CMT2N

Description

Alanyl-tRNA synthetase (HGNC Symbol)

Entrez gene summary

The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

q22.1

Chromosome location (bp)

70252295 - 70289543

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000090861 (version 83.38)

Entrez gene

16

UniProt

P49588 (UniProt - Evidence at protein level)

neXtProt

NX_P49588

Antibodypedia

AARS antibodies

PROTEIN BROWSER

AARS-001
AARS-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AARS-001
ENSP00000261772
ENST00000261772
P49588 [Direct mapping]
Alanine--tRNA ligase, cytoplasmic
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000049 [tRNA binding]
GO:0000166 [nucleotide binding]
GO:0001942 [hair follicle development]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0003676 [nucleic acid binding]
GO:0004813 [alanine-tRNA ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006400 [tRNA modification]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006419 [alanyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
GO:0006457 [protein folding]
GO:0008033 [tRNA processing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016597 [amino acid binding]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0021680 [cerebellar Purkinje cell layer development]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0034620 [cellular response to unfolded protein]
GO:0043039 [tRNA aminoacylation]
GO:0043200 [response to amino acid]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043588 [skin development]
GO:0046872 [metal ion binding]
GO:0050885 [neuromuscular process controlling balance]
GO:0050905 [neuromuscular process]
GO:0070062 [extracellular exosome]
Show all
968 aa
106.8 kDa
No 0
AARS-005
ENSP00000455360
ENST00000565361
H3BPK7 [Direct mapping]
Alanine--tRNA ligase, cytoplasmic
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0004813 [alanine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0006419 [alanyl-tRNA aminoacylation]
GO:0016876 [ligase activity, forming aminoacyl-tRNA and related compounds]
GO:0043039 [tRNA aminoacylation]
Show all
280 aa
30.1 kDa
No 0

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