Most malignant tissues showed moderate cytoplasmic staining. Several prostate and breast cancers along with a few malignant melanoma, squamous cell carcinoma and colorectal cancers were strongly stained.
Moderate cytoplasmic immunoreactivity was observed in most cancers. Several cases of ovarian and prostate cancers were strongly stained.
AARS (HGNC Symbol)
Alanyl-tRNA synthetase (HGNC Symbol)
Entrez gene summary
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]