Expression of TXNL1 in cancer - Summary

GENERAL INFORMATION
Gene name	TXNL1
Gene description	Thioredoxin-like 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in all tissues at variable levels, highest expression in the thyroid gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA002828 , HPA002829 , CAB016446
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and ovarian cancer (favourable).
Liver cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA002828	HPA002829	CAB016446

GENE INFORMATION
Gene name	TXNL1 (HGNC Symbol)
Synonyms	TRP32, Txl, TXNL
Description	Thioredoxin-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	18
Cytoband	q21.31
Chromosome location (bp)	56597208 - 56651600
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000091164 (version 83.38)
Entrez gene	9352
UniProt	O43396 (UniProt - Evidence at protein level)
neXtProt	NX_O43396
Antibodypedia	TXNL1 antibodies

PROTEIN BROWSER

TXNL1-001	TXNL1-002	TXNL1-004	TXNL1-005	TXNL1-006	TXNL1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TXNL1-001 ENSP00000217515 ENST00000217515	O43396 [Direct mapping] Thioredoxin-like protein 1 V9HW51 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 114; Thioredoxin-like 1, isoform CRA_c Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000103 [sulfate assimilation] GO:0000502 [proteasome complex] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006457 [protein folding] GO:0006662 [glycerol ether metabolic process] GO:0015035 [protein disulfide oxidoreductase activity] GO:0015036 [disulfide oxidoreductase activity] GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor] GO:0034599 [cellular response to oxidative stress] GO:0045454 [cell redox homeostasis] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	289 aa 32.3 kDa	No	0
TXNL1-002 ENSP00000464918 ENST00000590954	O43396 [Direct mapping] Thioredoxin-like protein 1 V9HW51 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 114; Thioredoxin-like 1, isoform CRA_c Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000103 [sulfate assimilation] GO:0000502 [proteasome complex] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006457 [protein folding] GO:0006662 [glycerol ether metabolic process] GO:0015035 [protein disulfide oxidoreductase activity] GO:0015036 [disulfide oxidoreductase activity] GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor] GO:0034599 [cellular response to oxidative stress] GO:0045454 [cell redox homeostasis] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	289 aa 32.3 kDa	No	0
TXNL1-004 ENSP00000468165 ENST00000586262	K7ER96 [Direct mapping] Thioredoxin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000103 [sulfate assimilation] GO:0005623 [cell] GO:0006457 [protein folding] GO:0006662 [glycerol ether metabolic process] GO:0015035 [protein disulfide oxidoreductase activity] GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor] GO:0034599 [cellular response to oxidative stress] GO:0045454 [cell redox homeostasis] GO:0055114 [oxidation-reduction process] Show all	281 aa 31.4 kDa	No	0
TXNL1-005 ENSP00000465606 ENST00000589329	K7EKG2 [Direct mapping] Thioredoxin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000103 [sulfate assimilation] GO:0005623 [cell] GO:0006457 [protein folding] GO:0015035 [protein disulfide oxidoreductase activity] GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor] GO:0034599 [cellular response to oxidative stress] GO:0045454 [cell redox homeostasis] GO:0055114 [oxidation-reduction process] Show all	27 aa 2.7 kDa	No	0
TXNL1-006 ENSP00000466558 ENST00000587613	K7EML9 [Direct mapping] Thioredoxin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000103 [sulfate assimilation] GO:0005623 [cell] GO:0006457 [protein folding] GO:0006662 [glycerol ether metabolic process] GO:0015035 [protein disulfide oxidoreductase activity] GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor] GO:0034599 [cellular response to oxidative stress] GO:0045454 [cell redox homeostasis] GO:0055114 [oxidation-reduction process] Show all	138 aa 15.5 kDa	No	0
TXNL1-008 ENSP00000466473 ENST00000589931	K7EME7 [Direct mapping] Thioredoxin-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000103 [sulfate assimilation] GO:0005623 [cell] GO:0006457 [protein folding] GO:0015035 [protein disulfide oxidoreductase activity] GO:0016671 [oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor] GO:0034599 [cellular response to oxidative stress] GO:0045454 [cell redox homeostasis] GO:0055114 [oxidation-reduction process] Show all	103 aa 12 kDa	No	0