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Gene name

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Chromosome

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Reliability

Reliability

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Validation

Method

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Cancer

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Detectable

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Detectable

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AC013461.1
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

AC013461.1

Gene description

Mitogen-activated protein kinase kinase kinase MLT

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (U-138 MG)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA017205
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA017205

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic staining was observed in a majority of cancer tissues. A few cases of liver cancers were strongly stained. Lymphomas and serval gliomas were negative.

GENE INFORMATION

Gene name

AC013461.1

Synonyms

Description

Mitogen-activated protein kinase kinase kinase MLT (UniProtKB/Swiss-Prot)

Entrez gene summary

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q31.1

Chromosome location (bp)

173075435 - 173268010

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000091436 (version 83.38)

Entrez gene

51776

UniProt

Q9NYL2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NYL2

Antibodypedia

AC013461.1 antibodies

PROTEIN BROWSER

AC013461.1-001
AC013461.1-002
AC013461.1-003
AC013461.1-006
AC013461.1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AC013461.1-001
ENSP00000364361
ENST00000375213
Q9NYL2 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase kinase MLT
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000075 [cell cycle checkpoint]
GO:0000077 [DNA damage checkpoint]
GO:0000186 [activation of MAPKK activity]
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007010 [cytoskeleton organization]
GO:0007050 [cell cycle arrest]
GO:0007257 [activation of JUN kinase activity]
GO:0008219 [cell death]
GO:0008283 [cell proliferation]
GO:0009314 [response to radiation]
GO:0030154 [cell differentiation]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
Show all
800 aa
91.2 kDa
No 0
AC013461.1-002
ENSP00000340257
ENST00000338983
D4Q8H0 [Direct mapping]
Mitogen-activated protein kinase kinase kinase MLT; Protein kinase
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
Show all
455 aa
51.6 kDa
No 0
AC013461.1-003
ENSP00000387259
ENST00000409176
Q9NYL2 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase kinase MLT
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000075 [cell cycle checkpoint]
GO:0000077 [DNA damage checkpoint]
GO:0000186 [activation of MAPKK activity]
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007050 [cell cycle arrest]
GO:0007257 [activation of JUN kinase activity]
GO:0008219 [cell death]
GO:0008283 [cell proliferation]
GO:0009314 [response to radiation]
GO:0030154 [cell differentiation]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
Show all
800 aa
91.2 kDa
No 0
AC013461.1-006
ENSP00000411923
ENST00000422149
C9J3F7 [Direct mapping]
Mitogen-activated protein kinase kinase kinase MLT
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
138 aa
15.8 kDa
No 0
AC013461.1-201
ENSP00000439414
ENST00000539448
D4Q8H0 [Direct mapping]
Mitogen-activated protein kinase kinase kinase MLT; Protein kinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
Show all
455 aa
51.6 kDa
No 0

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