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AC013461.1

GENERAL INFORMATION

Gene name

 AC013461.1

Gene description

 Mitogen-activated protein kinase kinase kinase MLT

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (U-138 MG)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA017205
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA017205

GENE INFORMATION

Gene name

 AC013461.1

Synonyms

Description

 Mitogen-activated protein kinase kinase kinase MLT (UniProtKB/Swiss-Prot)

Entrez gene summary

 This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 173075435 - 173268010

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000091436 (version 83.38)

Entrez gene

 51776

UniProt

 Q9NYL2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NYL2

Antibodypedia

 AC013461.1 antibodies

PROTEIN BROWSER
AC013461.1-001
AC013461.1-002
AC013461.1-003
AC013461.1-006
AC013461.1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AC013461.1-001
ENSP00000364361
ENST00000375213
Q9NYL2 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase kinase MLT
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000075 [cell cycle checkpoint]
GO:0000077 [DNA damage checkpoint]
GO:0000186 [activation of MAPKK activity]
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007010 [cytoskeleton organization]
GO:0007050 [cell cycle arrest]
GO:0007257 [activation of JUN kinase activity]
GO:0008219 [cell death]
GO:0008283 [cell proliferation]
GO:0009314 [response to radiation]
GO:0030154 [cell differentiation]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
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 800 aa
91.2 kDa 		No 0
AC013461.1-002
ENSP00000340257
ENST00000338983
D4Q8H0 [Direct mapping]
Mitogen-activated protein kinase kinase kinase MLT; Protein kinase
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
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 455 aa
51.6 kDa 		No 0
AC013461.1-003
ENSP00000387259
ENST00000409176
Q9NYL2 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase kinase MLT
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000075 [cell cycle checkpoint]
GO:0000077 [DNA damage checkpoint]
GO:0000186 [activation of MAPKK activity]
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007050 [cell cycle arrest]
GO:0007257 [activation of JUN kinase activity]
GO:0008219 [cell death]
GO:0008283 [cell proliferation]
GO:0009314 [response to radiation]
GO:0030154 [cell differentiation]
GO:0035556 [intracellular signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
Show all
 800 aa
91.2 kDa 		No 0
AC013461.1-006
ENSP00000411923
ENST00000422149
C9J3F7 [Direct mapping]
Mitogen-activated protein kinase kinase kinase MLT
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 138 aa
15.8 kDa 		No 0
AC013461.1-201
ENSP00000439414
ENST00000539448
D4Q8H0 [Direct mapping]
Mitogen-activated protein kinase kinase kinase MLT; Protein kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
Show all
 455 aa
51.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.