Weak to moderate cytoplasmic staining was observed in a majority of cancer tissues. A few cases of liver cancers were strongly stained. Lymphomas and serval gliomas were negative.
Mitogen-activated protein kinase kinase kinase MLT (UniProtKB/Swiss-Prot)
Entrez gene summary
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]