Fields »
ABOUT
HELP
BLOG
NLRP1

GENERAL INFORMATION

Gene name

 NLRP1

Gene description

 NLR family, pyrin domain containing 1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HDLM-2, Karpas-707, U-266/70)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues. Additional nuclear expression in neuronal cells, subsets of immune cells and cells in seminiferous ducts.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining in cells/structures not annotated, view images. GTEx data supports antibody staining in CNS while HPA RNA data does not.

Reliability score

 Supported based on 1 antibody.
CAB009189
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB009189

GENE INFORMATION

Gene name

 NLRP1 (HGNC Symbol)

Synonyms

 CARD7, CLR17.1, DEFCAP, DKFZp586O1822, KIAA0926, NAC, NALP1, SLEV1, VAMAS1

Description

 NLR family, pyrin domain containing 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 5499427 - 5619424

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000091592 (version 83.38)

Entrez gene

 22861

UniProt

 Q9C000 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9C000

Antibodypedia

 NLRP1 antibodies

PROTEIN BROWSER
NLRP1-001
NLRP1-009
NLRP1-010
NLRP1-011
NLRP1-012
NLRP1-014
NLRP1-201
NLRP1-202
NLRP1-203
NLRP1-204

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NLRP1-001
ENSP00000262467
ENST00000262467
Q9C000 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0032495 [response to muramyl dipeptide]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0045087 [innate immune response]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050727 [regulation of inflammatory response]
GO:0051402 [neuron apoptotic process]
GO:0072558 [NLRP1 inflammasome complex]
Show all
 1375 aa
154.9 kDa 		No 0
NLRP1-009
ENSP00000460216
ENST00000577119
Q9C000 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0032495 [response to muramyl dipeptide]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050727 [regulation of inflammatory response]
GO:0051402 [neuron apoptotic process]
GO:0072558 [NLRP1 inflammasome complex]
Show all
 1399 aa
157.3 kDa 		No 0
NLRP1-010
ENSP00000269280
ENST00000269280
Q9C000 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0032495 [response to muramyl dipeptide]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050727 [regulation of inflammatory response]
GO:0051402 [neuron apoptotic process]
GO:0072558 [NLRP1 inflammasome complex]
Show all
 1429 aa
160.9 kDa 		No 0
NLRP1-011
ENSP00000460475
ENST00000572272
Q9C000 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0032495 [response to muramyl dipeptide]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050727 [regulation of inflammatory response]
GO:0051402 [neuron apoptotic process]
GO:0072558 [NLRP1 inflammasome complex]
Show all
 1473 aa
165.9 kDa 		No 0
NLRP1-012
ENSP00000346390
ENST00000354411
Q9C000 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0032495 [response to muramyl dipeptide]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050727 [regulation of inflammatory response]
GO:0051402 [neuron apoptotic process]
GO:0072558 [NLRP1 inflammasome complex]
Show all
 1443 aa
162.2 kDa 		No 0
NLRP1-014
ENSP00000458303
ENST00000576905
I3L0S2 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 35 aa
4 kDa 		No 0
NLRP1-201
ENSP00000324366
ENST00000345221
Q9C000 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0032495 [response to muramyl dipeptide]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050727 [regulation of inflammatory response]
GO:0051402 [neuron apoptotic process]
GO:0072558 [NLRP1 inflammasome complex]
Show all
 1429 aa
160.9 kDa 		No 0
NLRP1-202
ENSP00000483359
ENST00000613500
Q9C000 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0032495 [response to muramyl dipeptide]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0045087 [innate immune response]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050727 [regulation of inflammatory response]
GO:0051402 [neuron apoptotic process]
GO:0072558 [NLRP1 inflammasome complex]
Show all
 1375 aa
154.9 kDa 		No 0
NLRP1-203
ENSP00000478516
ENST00000617618
Q9C000 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0032495 [response to muramyl dipeptide]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050727 [regulation of inflammatory response]
GO:0051402 [neuron apoptotic process]
GO:0072558 [NLRP1 inflammasome complex]
Show all
 1473 aa
165.9 kDa 		No 0
NLRP1-204
ENSP00000484692
ENST00000619223
Q9C000 [Direct mapping]
NACHT, LRR and PYD domains-containing protein 1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006954 [inflammatory response]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0019899 [enzyme binding]
GO:0019904 [protein domain specific binding]
GO:0032495 [response to muramyl dipeptide]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0042742 [defense response to bacterium]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050727 [regulation of inflammatory response]
GO:0051402 [neuron apoptotic process]
GO:0072558 [NLRP1 inflammasome complex]
Show all
 1443 aa
162.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.