Cell atlas - ORC6 - The Human Protein Atlas

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ORC6

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Nucleus

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ORC6
Gene description	Origin recognition complex, subunit 6
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the nucleoli (fibrillar center).
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Nucleoli fibrillar center (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA072587
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the nucleoli (fibrillar center).

Main location

Nucleus (approved)

Additional location

Nucleoli fibrillar center (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA072587	HEK 293	Nucleus
	HPA072587	HEK 293	Nucleoli fibrillar center
	HPA072587	PC-3	Nucleus
	HPA072587	PC-3	Nucleoli fibrillar center	Intensity
	HPA072587	U-2 OS	Nucleus

GENE INFORMATION
Gene name	ORC6 (HGNC Symbol)
Synonyms	ORC6L
Description	Origin recognition complex, subunit 6 (HGNC Symbol)
Entrez gene summary	The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]
Chromosome	16
Cytoband	q11.2
Chromosome location (bp)	46689643 - 46698394
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000091651 (version 83.38)
Entrez gene	23594
UniProt	Q9Y5N6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5N6
Antibodypedia	ORC6 antibodies

PROTEIN BROWSER

ORC6-001	ORC6-005	ORC6-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ORC6-001 ENSP00000219097 ENST00000219097	Q9Y5N6 [Direct mapping] Origin recognition complex subunit 6 A0A024R6R3 [Target identity:100%; Query identity:100%] Origin recognition complex, subunit 6 homolog-like (Yeast), isoform CRA_a Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0000808 [origin recognition complex] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005664 [nuclear origin of replication recognition complex] GO:0005886 [plasma membrane] GO:0006260 [DNA replication] GO:0006261 [DNA-dependent DNA replication] GO:0016020 [membrane] Show all	252 aa 28.1 kDa	No	0
ORC6-005 ENSP00000456981 ENST00000566860	H3BT22 [Direct mapping] Origin recognition complex subunit 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005664 [nuclear origin of replication recognition complex] GO:0006260 [DNA replication] Show all	203 aa 22.8 kDa	No	0
ORC6-006 ENSP00000457282 ENST00000568364	H3BTQ7 [Direct mapping] Origin recognition complex subunit 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0005664 [nuclear origin of replication recognition complex] GO:0005886 [plasma membrane] GO:0006260 [DNA replication] Show all	167 aa 18.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.