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ORC6

GENERAL INFORMATION

Gene name

 ORC6

Gene description

 Origin recognition complex, subunit 6

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several different tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB016330
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable) and melanoma (unfavourable).
Ovarian cancer p<0.001
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB016330

GENE INFORMATION

Gene name

 ORC6 (HGNC Symbol)

Synonyms

 ORC6L

Description

 Origin recognition complex, subunit 6 (HGNC Symbol)

Entrez gene summary

 The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]

Chromosome

 16

Cytoband

 q11.2

Chromosome location (bp)

 46689643 - 46698394

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000091651 (version 83.38)

Entrez gene

 23594

UniProt

 Q9Y5N6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5N6

Antibodypedia

 ORC6 antibodies

PROTEIN BROWSER
ORC6-001
ORC6-005
ORC6-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ORC6-001
ENSP00000219097
ENST00000219097
Q9Y5N6 [Direct mapping]
Origin recognition complex subunit 6
A0A024R6R3 [Target identity:100%; Query identity:100%]
Origin recognition complex, subunit 6 homolog-like (Yeast), isoform CRA_a
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000808 [origin recognition complex]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
GO:0006261 [DNA-dependent DNA replication]
GO:0016020 [membrane]
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 252 aa
28.1 kDa 		No 0
ORC6-005
ENSP00000456981
ENST00000566860
H3BT22 [Direct mapping]
Origin recognition complex subunit 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0006260 [DNA replication]
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 203 aa
22.8 kDa 		No 0
ORC6-006
ENSP00000457282
ENST00000568364
H3BTQ7 [Direct mapping]
Origin recognition complex subunit 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0005886 [plasma membrane]
GO:0006260 [DNA replication]
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 167 aa
18.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.