Cell atlas - ZC3HC1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ZC3HC1

premium

TISSUE

premium

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear membrane
	Nucleus

Human cell
	Nuclear membrane
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	ZC3HC1
Gene description	Zinc finger, C3HC-type containing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus & nuclear membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (supported), Nuclear membrane (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA024023
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus & nuclear membrane.

Main location

Nucleus (supported), Nuclear membrane (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA024023	A-431	Nucleus
	HPA024023	A-431	Nuclear membrane
	HPA024023	U-2 OS	Nucleus
	HPA024023	U-2 OS	Nuclear membrane
	HPA024023	U-251 MG	Nucleus
	HPA024023	U-251 MG	Nuclear membrane

GENE INFORMATION
Gene name	ZC3HC1 (HGNC Symbol)
Synonyms	NIPA
Description	Zinc finger, C3HC-type containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]
Chromosome	7
Cytoband	q32.2
Chromosome location (bp)	130018286 - 130051451
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000091732 (version 83.38)
Entrez gene	51530
UniProt	Q86WB0 (UniProt - Evidence at protein level)
neXtProt	NX_Q86WB0
Antibodypedia	ZC3HC1 antibodies

PROTEIN BROWSER

ZC3HC1-001	ZC3HC1-002	ZC3HC1-004	ZC3HC1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZC3HC1-001 ENSP00000351052 ENST00000358303	Q86WB0 [Direct mapping] Nuclear-interacting partner of ALK Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007067 [mitotic nuclear division] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0019901 [protein kinase binding] GO:0031965 [nuclear membrane] GO:0051301 [cell division] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] Show all	502 aa 55.3 kDa	No	0
ZC3HC1-002 ENSP00000353933 ENST00000360708	Q86WB0 [Direct mapping] Nuclear-interacting partner of ALK Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007067 [mitotic nuclear division] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0019901 [protein kinase binding] GO:0031965 [nuclear membrane] GO:0051301 [cell division] Show all	431 aa 47.8 kDa	No	0
ZC3HC1-004 ENSP00000418533 ENST00000481503	C9J0I9 [Direct mapping] Nuclear-interacting partner of ALK Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0008270 [zinc ion binding] Show all	459 aa 50.6 kDa	No	0
ZC3HC1-201 ENSP00000309301 ENST00000311873	Q86WB0 [Direct mapping] Nuclear-interacting partner of ALK Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007067 [mitotic nuclear division] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0019901 [protein kinase binding] GO:0031965 [nuclear membrane] GO:0051301 [cell division] Show all	481 aa 53.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.