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ZC3HC1

GENERAL INFORMATION

Gene name

 ZC3HC1

Gene description

 Zinc finger, C3HC-type containing 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA019089 , HPA024023
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019089
HPA024023

GENE INFORMATION

Gene name

 ZC3HC1 (HGNC Symbol)

Synonyms

 NIPA

Description

 Zinc finger, C3HC-type containing 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]

Chromosome

 7

Cytoband

 q32.2

Chromosome location (bp)

 130018286 - 130051451

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000091732 (version 83.38)

Entrez gene

 51530

UniProt

 Q86WB0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86WB0

Antibodypedia

 ZC3HC1 antibodies

PROTEIN BROWSER
ZC3HC1-001
ZC3HC1-002
ZC3HC1-004
ZC3HC1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZC3HC1-001
ENSP00000351052
ENST00000358303
Q86WB0 [Direct mapping]
Nuclear-interacting partner of ALK
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0007067 [mitotic nuclear division]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0031965 [nuclear membrane]
GO:0051301 [cell division]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
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 502 aa
55.3 kDa 		No 0
ZC3HC1-002
ENSP00000353933
ENST00000360708
Q86WB0 [Direct mapping]
Nuclear-interacting partner of ALK
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0007067 [mitotic nuclear division]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0031965 [nuclear membrane]
GO:0051301 [cell division]
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 431 aa
47.8 kDa 		No 0
ZC3HC1-004
ENSP00000418533
ENST00000481503
C9J0I9 [Direct mapping]
Nuclear-interacting partner of ALK
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0008270 [zinc ion binding]
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 459 aa
50.6 kDa 		No 0
ZC3HC1-201
ENSP00000309301
ENST00000311873
Q86WB0 [Direct mapping]
Nuclear-interacting partner of ALK
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0007067 [mitotic nuclear division]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0031965 [nuclear membrane]
GO:0051301 [cell division]
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 481 aa
53.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.