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ANGPT2

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GENERAL INFORMATION

Gene name

 ANGPT2

Gene description

 Angiopoietin 2

Protein class

 Cancer-related genes
Plasma proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Secreted

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (HUVEC TERT2, WM-115, HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HUVEC TERT2, WM-115, HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ANGPT2 (HGNC Symbol)

Synonyms

 Ang2

Description

 Angiopoietin 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 p23.1

Chromosome location (bp)

 6499651 - 6563409

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000091879 (version 83.38)

Entrez gene

 285

UniProt

 O15123 (UniProt - Evidence at protein level)

neXtProt

 NX_O15123

Antibodypedia

 ANGPT2 antibodies

PROTEIN BROWSER
ANGPT2-001
ANGPT2-002
ANGPT2-003
ANGPT2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANGPT2-001
ENSP00000314897
ENST00000325203
O15123 [Direct mapping]
Angiopoietin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001666 [response to hypoxia]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007281 [germ cell development]
GO:0007596 [blood coagulation]
GO:0009314 [response to radiation]
GO:0009612 [response to mechanical stimulus]
GO:0009749 [response to glucose]
GO:0010812 [negative regulation of cell-substrate adhesion]
GO:0014070 [response to organic cyclic compound]
GO:0014823 [response to activity]
GO:0016525 [negative regulation of angiogenesis]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031100 [organ regeneration]
GO:0042995 [cell projection]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0045766 [positive regulation of angiogenesis]
GO:0046872 [metal ion binding]
GO:0048014 [Tie signaling pathway]
GO:0048514 [blood vessel morphogenesis]
GO:0050900 [leukocyte migration]
GO:0050928 [negative regulation of positive chemotaxis]
GO:0060135 [maternal process involved in female pregnancy]
GO:0071363 [cellular response to growth factor stimulus]
GO:0072012 [glomerulus vasculature development]
Show all
 496 aa
56.9 kDa 		Yes 0
ANGPT2-002
ENSP00000343517
ENST00000338312
O15123 [Direct mapping]
Angiopoietin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0030971 [receptor tyrosine kinase binding]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0046872 [metal ion binding]
GO:0048014 [Tie signaling pathway]
GO:0050900 [leukocyte migration]
GO:0050928 [negative regulation of positive chemotaxis]
GO:0072012 [glomerulus vasculature development]
Show all
 444 aa
51 kDa 		Yes 0
ANGPT2-003
ENSP00000428023
ENST00000523120
E7EVQ3 [Direct mapping]
Angiopoietin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Show all
GO:0030971 [receptor tyrosine kinase binding]
Show all
 459 aa
52.6 kDa 		Yes 0
ANGPT2-004
ENSP00000486858
ENST00000629816
O15123 [Direct mapping]
Angiopoietin-2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0030971 [receptor tyrosine kinase binding]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0046872 [metal ion binding]
GO:0048014 [Tie signaling pathway]
GO:0050900 [leukocyte migration]
GO:0050928 [negative regulation of positive chemotaxis]
GO:0072012 [glomerulus vasculature development]
Show all
 495 aa
56.8 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.