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MYH7

GENERAL INFORMATION

Gene name

 MYH7

Gene description

 Myosin, heavy chain 7, cardiac muscle, beta

Protein class

 Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (heart muscle, skeletal muscle)
GTEx:Group enriched (heart muscle, skeletal muscle)
FANTOM5:Group enriched (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in heart and skeletal muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 3 antibodies.
HPA001239 , HPA001349 , CAB015384
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (heart muscle, skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (heart muscle, skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (heart muscle, skeletal muscle)

GENE INFORMATION

Gene name

 MYH7 (HGNC Symbol)

Synonyms

 CMD1S, CMH1, MPD1

Description

 Myosin, heavy chain 7, cardiac muscle, beta (HGNC Symbol)

Entrez gene summary

 Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 23412738 - 23435718

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092054 (version 83.38)

Entrez gene

 4625

UniProt

 P12883 (UniProt - Evidence at protein level)

neXtProt

 NX_P12883

Antibodypedia

 MYH7 antibodies

PROTEIN BROWSER
MYH7-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYH7-001
ENSP00000347507
ENST00000355349
P12883 [Direct mapping]
Myosin-7
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Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000146 [microfilament motor activity]
GO:0001725 [stress fiber]
GO:0002026 [regulation of the force of heart contraction]
GO:0002027 [regulation of heart rate]
GO:0003009 [skeletal muscle contraction]
GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005859 [muscle myosin complex]
GO:0005925 [focal adhesion]
GO:0006936 [muscle contraction]
GO:0006941 [striated muscle contraction]
GO:0007512 [adult heart development]
GO:0014728 [regulation of the force of skeletal muscle contraction]
GO:0014883 [transition between fast and slow fiber]
GO:0016459 [myosin complex]
GO:0016887 [ATPase activity]
GO:0030016 [myofibril]
GO:0030017 [sarcomere]
GO:0030018 [Z disc]
GO:0030049 [muscle filament sliding]
GO:0030898 [actin-dependent ATPase activity]
GO:0031449 [regulation of slow-twitch skeletal muscle fiber contraction]
GO:0032982 [myosin filament]
GO:0042803 [protein homodimerization activity]
GO:0046034 [ATP metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
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 1935 aa
223.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.