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CEBPE

GENERAL INFORMATION

Gene name

 CEBPE

Gene description

 CCAAT/enhancer binding protein (C/EBP), epsilon

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enhanced (HL-60, HMC-1, NB-4)
HPA (normal tissue):Tissue enriched (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in bone marrow poietic cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA002928 , CAB005113
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA002928
CAB005113

GENE INFORMATION

Gene name

 CEBPE (HGNC Symbol)

Synonyms

 CRP1

Description

 CCAAT/enhancer binding protein (C/EBP), epsilon (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 23117304 - 23119616

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092067 (version 83.38)

Entrez gene

 1053

UniProt

 Q15744 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15744

Antibodypedia

 CEBPE antibodies

PROTEIN BROWSER
CEBPE-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CEBPE-001
ENSP00000206513
ENST00000206513
Q15744 [Direct mapping]
CCAAT/enhancer-binding protein epsilon
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Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006909 [phagocytosis]
GO:0006952 [defense response]
GO:0010628 [positive regulation of gene expression]
GO:0030099 [myeloid cell differentiation]
GO:0030225 [macrophage differentiation]
GO:0042089 [cytokine biosynthetic process]
GO:0042742 [defense response to bacterium]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046982 [protein heterodimerization activity]
GO:0071222 [cellular response to lipopolysaccharide]
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 281 aa
30.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.