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SUPT16H

GENERAL INFORMATION

Gene name

 SUPT16H

Gene description

 SPT16 homolog, facilitates chromatin remodeling subunit

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear or nucleolar expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA049787 , CAB022551
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049787
CAB022551

GENE INFORMATION

Gene name

 SUPT16H (HGNC Symbol)

Synonyms

 CDC68, FACT, FACTP140, FLJ10857, FLJ14010, SPT16/CDC68

Description

 SPT16 homolog, facilitates chromatin remodeling subunit (HGNC Symbol)

Entrez gene summary

 Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 21351472 - 21384266

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092201 (version 83.38)

Entrez gene

 11198

UniProt

 Q9Y5B9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5B9

Antibodypedia

 SUPT16H antibodies

PROTEIN BROWSER
SUPT16H-001
SUPT16H-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SUPT16H-001
ENSP00000216297
ENST00000216297
Q9Y5B9 [Direct mapping]
FACT complex subunit SPT16
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Enzymes
   Peptidases
   Metallopeptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006337 [nucleosome disassembly]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032786 [positive regulation of DNA-templated transcription, elongation]
GO:0044822 [poly(A) RNA binding]
GO:0050434 [positive regulation of viral transcription]
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 1047 aa
119.9 kDa 		No 0
SUPT16H-003
ENSP00000450910
ENST00000555943
G3V2X0 [Direct mapping]
FACT complex subunit SPT16
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 83 aa
9.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.