Fields »
ABOUT
HELP
BLOG
SUPT16H

GENERAL INFORMATION

Gene name

 SUPT16H

Gene description

 SPT16 homolog, facilitates chromatin remodeling subunit

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear or nucleolar expression in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA049787 , CAB022551
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SUPT16H (HGNC Symbol)

Synonyms

 CDC68, FACT, FACTP140, FLJ10857, FLJ14010, SPT16/CDC68

Description

 SPT16 homolog, facilitates chromatin remodeling subunit (HGNC Symbol)

Entrez gene summary

 Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]

Chromosome

 14

Cytoband

 q11.2

Chromosome location (bp)

 21351472 - 21384266

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092201 (version 83.38)

Entrez gene

 11198

UniProt

 Q9Y5B9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5B9

Antibodypedia

 SUPT16H antibodies

PROTEIN BROWSER
SUPT16H-001
SUPT16H-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SUPT16H-001
ENSP00000216297
ENST00000216297
Q9Y5B9 [Direct mapping]
FACT complex subunit SPT16
Show all
Enzymes
   Peptidases
   Metallopeptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006337 [nucleosome disassembly]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032786 [positive regulation of DNA-templated transcription, elongation]
GO:0044822 [poly(A) RNA binding]
GO:0050434 [positive regulation of viral transcription]
Show all
 1047 aa
119.9 kDa 		No 0
SUPT16H-003
ENSP00000450910
ENST00000555943
G3V2X0 [Direct mapping]
FACT complex subunit SPT16
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 83 aa
9.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.