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GEMIN2

GENERAL INFORMATION

Gene name

 GEMIN2

Gene description

 Gem (nuclear organelle) associated protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic or nuclear expression in several tissues with highest levels in testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA046570 , CAB015426
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 GEMIN2 (HGNC Symbol)

Synonyms

 SIP1

Description

 Gem (nuclear organelle) associated protein 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]

Chromosome

 14

Cytoband

 q21.1

Chromosome location (bp)

 39114223 - 39136973

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092208 (version 83.38)

Entrez gene

 8487

UniProt

 O14893 (UniProt - Evidence at protein level)

neXtProt

 NX_O14893

Antibodypedia

 GEMIN2 antibodies

PROTEIN BROWSER
GEMIN2-001
GEMIN2-002
GEMIN2-003
GEMIN2-009
GEMIN2-010
GEMIN2-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GEMIN2-001
ENSP00000308533
ENST00000308317
O14893 [Direct mapping]
Gem-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000387 [spliceosomal snRNP assembly]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0032797 [SMN complex]
GO:0034660 [ncRNA metabolic process]
GO:0034719 [SMN-Sm protein complex]
GO:0097504 [Gemini of coiled bodies]
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 280 aa
31.6 kDa 		No 0
GEMIN2-002
ENSP00000250379
ENST00000250379
O14893 [Direct mapping]
Gem-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000387 [spliceosomal snRNP assembly]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0032797 [SMN complex]
GO:0034660 [ncRNA metabolic process]
GO:0034719 [SMN-Sm protein complex]
GO:0097504 [Gemini of coiled bodies]
Show all
 265 aa
29.9 kDa 		No 0
GEMIN2-003
ENSP00000379548
ENST00000396249
O14893 [Direct mapping]
Gem-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0000375 [RNA splicing, via transesterification reactions]
GO:0000387 [spliceosomal snRNP assembly]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006397 [mRNA processing]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0032797 [SMN complex]
GO:0034660 [ncRNA metabolic process]
GO:0034719 [SMN-Sm protein complex]
GO:0097504 [Gemini of coiled bodies]
Show all
 250 aa
28.2 kDa 		No 0
GEMIN2-009
ENSP00000436065
ENST00000534684
H0YEL0 [Direct mapping]
Gem-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0005681 [spliceosomal complex]
Show all
 220 aa
24.5 kDa 		No 0
GEMIN2-010
ENSP00000434048
ENST00000527381
H0YDP6 [Direct mapping]
Gem-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0005681 [spliceosomal complex]
Show all
 198 aa
22 kDa 		No 0
GEMIN2-012
ENSP00000474979
ENST00000524781
S4R421 [Direct mapping]
Gem-associated protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 22 aa
2.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.