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RNA cell line category: Cell line enriched (SK-MEL-30)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
GENE INFORMATION
Gene name
CAPN3 (HGNC Symbol)
Synonyms
CANP3, LGMD2, LGMD2A, nCL-1, p94
Description
Calpain 3 (HGNC Symbol)
Entrez gene summary
Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001896 [autolysis] GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045661 [regulation of myoblast differentiation] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0070315 [G1 to G0 transition involved in cell differentiation] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity] GO:0004198 [calcium-dependent cysteine-type endopeptidase activity] GO:0004871 [signal transducer activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006461 [protein complex assembly] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007517 [muscle organ development] GO:0008233 [peptidase activity] GO:0008234 [cysteine-type peptidase activity] GO:0008307 [structural constituent of muscle] GO:0014718 [positive regulation of satellite cell activation involved in skeletal muscle regeneration] GO:0014850 [response to muscle activity] GO:0030016 [myofibril] GO:0030018 [Z disc] GO:0030239 [myofibril assembly] GO:0030315 [T-tubule] GO:0031402 [sodium ion binding] GO:0031432 [titin binding] GO:0032947 [protein complex scaffold] GO:0033234 [negative regulation of protein sumoylation] GO:0043066 [negative regulation of apoptotic process] GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043234 [protein complex] GO:0045214 [sarcomere organization] GO:0045862 [positive regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046716 [muscle cell cellular homeostasis] GO:0050790 [regulation of catalytic activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol] GO:0051592 [response to calcium ion] GO:0055103 [ligase regulator activity] GO:0061061 [muscle structure development] GO:0071277 [cellular response to calcium ion] GO:0071472 [cellular response to salt stress] GO:0072657 [protein localization to membrane] GO:0097264 [self proteolysis]