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SNAP23

GENERAL INFORMATION

Gene name

 SNAP23

Gene description

 Synaptosomal-associated protein, 23kDa

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 3 antibodies.
HPA001214 , CAB037083 , CAB037317
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001214
CAB037083
CAB037317

GENE INFORMATION

Gene name

 SNAP23 (HGNC Symbol)

Synonyms

 HsT17016, SNAP23A, SNAP23B

Description

 Synaptosomal-associated protein, 23kDa (HGNC Symbol)

Entrez gene summary

 Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

Chromosome location (bp)

 42491233 - 42545356

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092531 (version 83.38)

Entrez gene

 8773

UniProt

 O00161 (UniProt - Evidence at protein level)

neXtProt

 NX_O00161

Antibodypedia

 SNAP23 antibodies

PROTEIN BROWSER
«
SNAP23-001
SNAP23-002
SNAP23-003
SNAP23-008
SNAP23-009
SNAP23-012
SNAP23-015
SNAP23-017
SNAP23-018
SNAP23-019
SNAP23-201
SNAP23-202
SNAP23-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNAP23-001
ENSP00000249647
ENST00000249647
O00161 [Direct mapping]
Synaptosomal-associated protein 23
A8K287 [Target identity:100%; Query identity:100%]
Synaptosomal-associated protein
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002553 [histamine secretion by mast cell]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006887 [exocytosis]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006903 [vesicle targeting]
GO:0015031 [protein transport]
GO:0016082 [synaptic vesicle priming]
GO:0019905 [syntaxin binding]
GO:0031201 [SNARE complex]
GO:0031410 [cytoplasmic vesicle]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0042581 [specific granule]
GO:0042582 [azurophil granule]
GO:0042629 [mast cell granule]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0061024 [membrane organization]
GO:0061025 [membrane fusion]
GO:0070062 [extracellular exosome]
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 211 aa
23.4 kDa 		No 0
SNAP23-002
ENSP00000380327
ENST00000397138
O00161 [Direct mapping]
Synaptosomal-associated protein 23
A0A024R9R8 [Target identity:100%; Query identity:100%]
Synaptosomal-associated protein, 23kDa, isoform CRA_b
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002553 [histamine secretion by mast cell]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006887 [exocytosis]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006903 [vesicle targeting]
GO:0015031 [protein transport]
GO:0016082 [synaptic vesicle priming]
GO:0019905 [syntaxin binding]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0042581 [specific granule]
GO:0042582 [azurophil granule]
GO:0042629 [mast cell granule]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0061024 [membrane organization]
GO:0061025 [membrane fusion]
GO:0070062 [extracellular exosome]
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 158 aa
17.8 kDa 		No 0
SNAP23-003
ENSP00000454214
ENST00000561526
H3BM38 [Direct mapping]
Synaptosomal-associated protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0006887 [exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0043005 [neuron projection]
Show all
 125 aa
13.9 kDa 		No 0
SNAP23-008
ENSP00000455339
ENST00000564153
H3BPJ0 [Direct mapping]
Synaptosomal-associated protein 23
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005623 [cell]
GO:0006887 [exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
Show all
 127 aa
14.3 kDa 		No 0
SNAP23-009
ENSP00000458012
ENST00000566327
H3BV99 [Direct mapping]
Synaptosomal-associated protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
GO:0006887 [exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0043005 [neuron projection]
Show all
 142 aa
15.6 kDa 		No 0
SNAP23-012
ENSP00000456035
ENST00000568859
H3BR18 [Direct mapping]
Synaptosomal-associated protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005623 [cell]
GO:0006887 [exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
Show all
 109 aa
12.3 kDa 		No 0
SNAP23-015
ENSP00000455472
ENST00000567094
H3BNE1 [Direct mapping]
Synaptosomal-associated protein 23
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005623 [cell]
GO:0006887 [exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
Show all
 97 aa
11.1 kDa 		No 0
SNAP23-017
ENSP00000456000
ENST00000563830
H3BQY9 [Direct mapping]
Synaptosomal-associated protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0006887 [exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0043005 [neuron projection]
Show all
 154 aa
16.9 kDa 		No 0
SNAP23-018
ENSP00000455102
ENST00000568841
H3BP15 [Direct mapping]
Synaptosomal-associated protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0006887 [exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0043005 [neuron projection]
Show all
 149 aa
16.2 kDa 		No 0
SNAP23-019
ENSP00000456144
ENST00000563873
H3BR99 [Direct mapping]
Synaptosomal-associated protein 23
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005623 [cell]
GO:0006887 [exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
Show all
 90 aa
10.2 kDa 		No 0
SNAP23-201
ENSP00000207062
ENST00000349777
O00161 [Direct mapping]
Synaptosomal-associated protein 23
A0A024R9R8 [Target identity:100%; Query identity:100%]
Synaptosomal-associated protein, 23kDa, isoform CRA_b
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002553 [histamine secretion by mast cell]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006887 [exocytosis]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006903 [vesicle targeting]
GO:0015031 [protein transport]
GO:0016082 [synaptic vesicle priming]
GO:0019905 [syntaxin binding]
GO:0031201 [SNARE complex]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
GO:0042581 [specific granule]
GO:0042582 [azurophil granule]
GO:0042629 [mast cell granule]
GO:0043005 [neuron projection]
GO:0045202 [synapse]
GO:0061024 [membrane organization]
GO:0061025 [membrane fusion]
GO:0070062 [extracellular exosome]
Show all
 158 aa
17.8 kDa 		No 0
SNAP23-202
ENSP00000486335
ENST00000626061
H3BU94 [Direct mapping]
Synaptosomal-associated protein 23
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0005623 [cell]
GO:0006887 [exocytosis]
GO:0016021 [integral component of membrane]
GO:0016082 [synaptic vesicle priming]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
Show all
 53 aa
6 kDa 		No 1
SNAP23-203
ENSP00000485888
ENST00000627440
H3BNG6 [Direct mapping]
Synaptosomal-associated protein 23
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005484 [SNAP receptor activity]
GO:0005623 [cell]
GO:0006887 [exocytosis]
GO:0016082 [synaptic vesicle priming]
GO:0031629 [synaptic vesicle fusion to presynaptic membrane]
Show all
 44 aa
5.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.