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PHGDH

GENERAL INFORMATION

Gene name

 PHGDH

Gene description

 Phosphoglycerate dehydrogenase

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 4 antibodies.
HPA021241 , HPA024031 , CAB003681 , CAB068216
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and glioma (favourable).
Endometrial cancer p<0.001
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA021241
HPA024031
CAB003681
CAB068216

GENE INFORMATION

Gene name

 PHGDH (HGNC Symbol)

Synonyms

 PDG, PGDH, SERA

Description

 Phosphoglycerate dehydrogenase (HGNC Symbol)

Entrez gene summary

 This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]

Chromosome

 1

Cytoband

 p12

Chromosome location (bp)

 119659798 - 119744215

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000092621 (version 83.38)

Entrez gene

 26227

UniProt

 O43175 (UniProt - Evidence at protein level)

neXtProt

 NX_O43175

Antibodypedia

 PHGDH antibodies

PROTEIN BROWSER
PHGDH-001
PHGDH-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PHGDH-001
ENSP00000358417
ENST00000369409
O43175 [Direct mapping]
D-3-phosphoglycerate dehydrogenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004617 [phosphoglycerate dehydrogenase activity]
GO:0005829 [cytosol]
GO:0006541 [glutamine metabolic process]
GO:0006544 [glycine metabolic process]
GO:0006563 [L-serine metabolic process]
GO:0006564 [L-serine biosynthetic process]
GO:0006566 [threonine metabolic process]
GO:0007420 [brain development]
GO:0008152 [metabolic process]
GO:0008652 [cellular amino acid biosynthetic process]
GO:0009055 [electron carrier activity]
GO:0009070 [serine family amino acid biosynthetic process]
GO:0009448 [gamma-aminobutyric acid metabolic process]
GO:0010468 [regulation of gene expression]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019530 [taurine metabolic process]
GO:0021510 [spinal cord development]
GO:0021782 [glial cell development]
GO:0021915 [neural tube development]
GO:0022008 [neurogenesis]
GO:0031175 [neuron projection development]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0043209 [myelin sheath]
GO:0044281 [small molecule metabolic process]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0070314 [G1 to G0 transition]
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 533 aa
56.6 kDa 		No 0
PHGDH-002
ENSP00000358415
ENST00000369407
Q5SZU1 [Direct mapping]
D-3-phosphoglycerate dehydrogenase
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   SPOCTOPUS predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004617 [phosphoglycerate dehydrogenase activity]
GO:0006564 [L-serine biosynthetic process]
GO:0008152 [metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
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 499 aa
53.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.