Cell atlas - COL9A3 - The Human Protein Atlas

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COL9A3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Intermediate filaments
	Nucleoplasm

Human cell
	Intermediate Filaments
	Nucleoplasm

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GENERAL INFORMATION
Gene name	COL9A3
Gene description	Collagen, type IX, alpha 3
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the intermediate filaments.
RNA cell category	Group enriched (BEWO, WM-115, Hep G2, SK-MEL-30)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Intermediate filaments (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA058323
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (BEWO, WM-115, Hep G2, SK-MEL-30) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the intermediate filaments.

Main location

Nucleoplasm (approved)

Additional location

Intermediate filaments (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA058323	HeLa	Nucleoplasm
	HPA058323	Hep G2	Nucleoplasm
	HPA058323	U-2 OS	Nucleoplasm
	HPA058323	U-2 OS	Intermediate filaments

GENE INFORMATION
Gene name	COL9A3 (HGNC Symbol)
Synonyms	DJ885L7.4.1, EDM3, FLJ90759, IDD, MED
Description	Collagen, type IX, alpha 3 (HGNC Symbol)
Entrez gene summary	This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. Mutations in this gene are associated with multiple epiphyseal dysplasia type 3. [provided by RefSeq, Jan 2010]
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	62816244 - 62841159
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000092758 (version 83.38)
Entrez gene	1299
UniProt	Q14050 (UniProt - Evidence at protein level)
neXtProt	NX_Q14050
Antibodypedia	COL9A3 antibodies

PROTEIN BROWSER

COL9A3-001	COL9A3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COL9A3-001 ENSP00000341640 ENST00000343916	Q14050 [Direct mapping] Collagen alpha-3(IX) chain Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005594 [collagen type IX trimer] GO:0005788 [endoplasmic reticulum lumen] GO:0007411 [axon guidance] GO:0008584 [male gonad development] GO:0008585 [female gonad development] GO:0022617 [extracellular matrix disassembly] GO:0030020 [extracellular matrix structural constituent conferring tensile strength] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] Show all	684 aa 63.6 kDa	Yes	0
COL9A3-005 ENSP00000394280 ENST00000452372	Q4VXW1 [Direct mapping] Collagen alpha-3(IX) chain Show all	Predicted intracellular proteins Show all		191 aa 17.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.