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NUP50

GENERAL INFORMATION

Gene name

 NUP50

Gene description

 Nucleoporin 50kDa

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA047162
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 NUP50 (HGNC Symbol)

Synonyms

 NPAP60L

Description

 Nucleoporin 50kDa (HGNC Symbol)

Entrez gene summary

 The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins that functions as a soluble cofactor in importin-alpha:beta-mediated nuclear protein import. Pseudogenes of this gene are found on chromosomes 5, 6, and 14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q13.31

Chromosome location (bp)

 45163841 - 45188015

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000093000 (version 83.38)

Entrez gene

 10762

UniProt

 Q9UKX7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKX7

Antibodypedia

 NUP50 antibodies

PROTEIN BROWSER
NUP50-001
NUP50-002
NUP50-003
NUP50-005
NUP50-007
NUP50-010
NUP50-011
NUP50-013
NUP50-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUP50-001
ENSP00000345895
ENST00000347635
Q9UKX7 [Direct mapping]
Nuclear pore complex protein Nup50
A0A024R4X7 [Target identity:100%; Query identity:100%]
HCG1989366, isoform CRA_a
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046907 [intracellular transport]
GO:0051028 [mRNA transport]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
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 468 aa
50.1 kDa 		No 0
NUP50-002
ENSP00000385555
ENST00000407019
Q9UKX7 [Direct mapping]
Nuclear pore complex protein Nup50
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046907 [intracellular transport]
GO:0051028 [mRNA transport]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 440 aa
46.9 kDa 		No 0
NUP50-003
ENSP00000379403
ENST00000396096
Q9UKX7 [Direct mapping]
Nuclear pore complex protein Nup50
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005975 [carbohydrate metabolic process]
GO:0007077 [mitotic nuclear envelope disassembly]
GO:0008033 [tRNA processing]
GO:0008645 [hexose transport]
GO:0010467 [gene expression]
GO:0010827 [regulation of glucose transport]
GO:0015031 [protein transport]
GO:0015758 [glucose transport]
GO:0016032 [viral process]
GO:0016925 [protein sumoylation]
GO:0019048 [modulation by virus of host morphology or physiology]
GO:0019054 [modulation by virus of host process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031047 [gene silencing by RNA]
GO:0031965 [nuclear membrane]
GO:0034605 [cellular response to heat]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046907 [intracellular transport]
GO:0051028 [mRNA transport]
GO:0055085 [transmembrane transport]
GO:1900034 [regulation of cellular response to heat]
Show all
 440 aa
46.9 kDa 		No 0
NUP50-005
ENSP00000415062
ENST00000424634
X6RKQ2 [Direct mapping]
Nuclear pore complex protein Nup50
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005643 [nuclear pore]
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 45 aa
5.3 kDa 		No 0
NUP50-007
ENSP00000394450
ENST00000417702
A0A0G2JI20 [Direct mapping]
Nuclear pore complex protein Nup50
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 8 aa
0.9 kDa 		No 0
NUP50-010
ENSP00000397960
ENST00000430547
B1AHA5 [Direct mapping]
Nuclear pore complex protein Nup50
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   Phobius predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0016021 [integral component of membrane]
GO:0031965 [nuclear membrane]
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 76 aa
8.8 kDa 		No 0
NUP50-011
ENSP00000398297
ENST00000445721
A0A0G2JIF9 [Direct mapping]
Nuclear pore complex protein Nup50
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 10 aa
1.2 kDa 		No 0
NUP50-013
ENSP00000400465
ENST00000432340
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 4 aa
0.5 kDa 		No 0
NUP50-017
ENSP00000416264
ENST00000422489
B0QY21 [Direct mapping]
Nuclear pore complex protein Nup50
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0031965 [nuclear membrane]
GO:0046907 [intracellular transport]
Show all
 178 aa
19.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.