Cell atlas - COMT - The Human Protein Atlas

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COMT

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS GFP

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum
	Vesicles

Human cell
	Endoplasmic Reticulum
	Vesicles

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GENERAL INFORMATION
Gene name	COMT
Gene description	Catechol-O-methyltransferase
Protein class	Enzymes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles. In addition localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Additional location	In addition localized to the Endoplasmic reticulum (approved)
GFP	The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA001169
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles. In addition localized to the endoplasmic reticulum.

Main location

Vesicles (approved)

Additional location

Endoplasmic reticulum (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001169	A-431	Vesicles
	HPA001169	U-2 OS	Vesicles
	HPA001169	U-251 MG	Vesicles

GFP

Antibody	HPA001169
Validation	C-terminal tag BAC cell line: 5885 Validated: Antibody staining overlaps with GFP tagged protein


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	BAC id	Tag	Location antibody staining	Location tagged protein
	HPA001169	HeLa	5885	C-terminal	Endoplasmic reticulum	Endoplasmic reticulum
	HPA001169	HeLa	Normal	-	Nucleus, Vesicles	-

GENE INFORMATION
Gene name	COMT
Synonyms
Description	Catechol-O-methyltransferase (HGNC Symbol)
Entrez gene summary	Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	19941607 - 19969975
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000093010 (version 83.38)
Entrez gene	1312
UniProt	P21964 (UniProt - Evidence at protein level)
neXtProt	NX_P21964
Antibodypedia	COMT antibodies

PROTEIN BROWSER

COMT-001	COMT-002	COMT-003	COMT-004	COMT-005	COMT-008	COMT-011	COMT-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COMT-001 ENSP00000385150 ENST00000406520	P21964 [Direct mapping] Catechol O-methyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006584 [catecholamine metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007268 [synaptic transmission] GO:0008171 [O-methyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016206 [catechol O-methyltransferase activity] GO:0032259 [methylation] GO:0042135 [neurotransmitter catabolic process] GO:0042136 [neurotransmitter biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	271 aa 30 kDa	No	0
COMT-002 ENSP00000385917 ENST00000403710	P21964 [Direct mapping] Catechol O-methyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006584 [catecholamine metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007268 [synaptic transmission] GO:0008171 [O-methyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016206 [catechol O-methyltransferase activity] GO:0032259 [methylation] GO:0042135 [neurotransmitter catabolic process] GO:0042136 [neurotransmitter biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	271 aa 30 kDa	No	0
COMT-003 ENSP00000384654 ENST00000407537	P21964 [Direct mapping] Catechol O-methyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006584 [catecholamine metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007268 [synaptic transmission] GO:0008171 [O-methyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016206 [catechol O-methyltransferase activity] GO:0032259 [methylation] GO:0042135 [neurotransmitter catabolic process] GO:0042136 [neurotransmitter biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	271 aa 30 kDa	No	0
COMT-004 ENSP00000383966 ENST00000403184	E7EUU8 [Direct mapping] Catechol O-methyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0006584 [catecholamine metabolic process] GO:0008171 [O-methyltransferase activity] GO:0016206 [catechol O-methyltransferase activity] GO:0032259 [methylation] GO:0042135 [neurotransmitter catabolic process] Show all	235 aa 26 kDa	No	0
COMT-005 ENSP00000403958 ENST00000412786	E7EMS6 [Direct mapping] Catechol O-methyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0006584 [catecholamine metabolic process] GO:0008171 [O-methyltransferase activity] GO:0016206 [catechol O-methyltransferase activity] GO:0032259 [methylation] GO:0042135 [neurotransmitter catabolic process] Show all	223 aa 24.8 kDa	No	0
COMT-008 ENSP00000387695 ENST00000428707	H7BZ45 [Direct mapping] Catechol O-methyltransferase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008171 [O-methyltransferase activity] GO:0032259 [methylation] Show all	152 aa 16.8 kDa	No	1
COMT-011 ENSP00000354511 ENST00000361682	P21964 [Direct mapping] Catechol O-methyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006584 [catecholamine metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007268 [synaptic transmission] GO:0007565 [female pregnancy] GO:0007612 [learning] GO:0007614 [short-term memory] GO:0008171 [O-methyltransferase activity] GO:0008210 [estrogen metabolic process] GO:0009712 [catechol-containing compound metabolic process] GO:0014070 [response to organic cyclic compound] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016036 [cellular response to phosphate starvation] GO:0016206 [catechol O-methyltransferase activity] GO:0030424 [axon] GO:0030425 [dendrite] GO:0032259 [methylation] GO:0032496 [response to lipopolysaccharide] GO:0032502 [developmental process] GO:0035814 [negative regulation of renal sodium excretion] GO:0042135 [neurotransmitter catabolic process] GO:0042136 [neurotransmitter biosynthetic process] GO:0042417 [dopamine metabolic process] GO:0042420 [dopamine catabolic process] GO:0042493 [response to drug] GO:0043197 [dendritic spine] GO:0044281 [small molecule metabolic process] GO:0044297 [cell body] GO:0045211 [postsynaptic membrane] GO:0045963 [negative regulation of dopamine metabolic process] GO:0048265 [response to pain] GO:0048609 [multicellular organismal reproductive process] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0050668 [positive regulation of homocysteine metabolic process] GO:0051930 [regulation of sensory perception of pain] GO:0070062 [extracellular exosome] Show all	271 aa 30 kDa	No	0
COMT-012 ENSP00000416778 ENST00000449653	P21964 [Direct mapping] Catechol O-methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006584 [catecholamine metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0007268 [synaptic transmission] GO:0008171 [O-methyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016206 [catechol O-methyltransferase activity] GO:0032259 [methylation] GO:0042135 [neurotransmitter catabolic process] GO:0042136 [neurotransmitter biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0070062 [extracellular exosome] Show all	221 aa 24.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.