Expression of LRRFIP2 in cancer - Summary - The Human Protein Atlas

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LRRFIP2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LRRFIP2
Gene description	Leucine rich repeat (in FLII) interacting protein 2
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA035956
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035956

GENE INFORMATION
Gene name	LRRFIP2 (HGNC Symbol)
Synonyms	HUFI-2
Description	Leucine rich repeat (in FLII) interacting protein 2 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	37052656 - 37183689
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000093167 (version 83.38)
Entrez gene	9209
UniProt	Q9Y608 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y608
Antibodypedia	LRRFIP2 antibodies

PROTEIN BROWSER

LRRFIP2-001	LRRFIP2-002	LRRFIP2-003	LRRFIP2-004	LRRFIP2-006	LRRFIP2-012	LRRFIP2-017	LRRFIP2-018	LRRFIP2-019	LRRFIP2-021	LRRFIP2-023

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRFIP2-001 ENSP00000338727 ENST00000336686	Q9Y608 [Direct mapping] Leucine-rich repeat flightless-interacting protein 2 Show all	Predicted intracellular proteins Transcription factors Yet undefined DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0016055 [Wnt signaling pathway] GO:0030275 [LRR domain binding] Show all	721 aa 82.2 kDa	No	0
LRRFIP2-002 ENSP00000346349 ENST00000354379	Q9Y608 [Direct mapping] Leucine-rich repeat flightless-interacting protein 2 Show all	Predicted intracellular proteins Transcription factors Yet undefined DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0016055 [Wnt signaling pathway] GO:0030275 [LRR domain binding] Show all	400 aa 45.4 kDa	No	0
LRRFIP2-003 ENSP00000416364 ENST00000421276	Q9Y608 [Direct mapping] Leucine-rich repeat flightless-interacting protein 2 Show all	Predicted intracellular proteins Transcription factors Yet undefined DNA-binding domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0016055 [Wnt signaling pathway] GO:0030275 [LRR domain binding] Show all	424 aa 48.3 kDa	No	0
LRRFIP2-004 ENSP00000405480 ENST00000440230	Q9Y608 [Direct mapping] Leucine-rich repeat flightless-interacting protein 2 Show all	Predicted intracellular proteins Transcription factors Yet undefined DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0016055 [Wnt signaling pathway] GO:0030275 [LRR domain binding] Show all	424 aa 48.3 kDa	No	0
LRRFIP2-006 ENSP00000379705 ENST00000396428	Q9Y608 [Direct mapping] Leucine-rich repeat flightless-interacting protein 2 Show all	Predicted intracellular proteins Transcription factors Yet undefined DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0016055 [Wnt signaling pathway] GO:0030275 [LRR domain binding] Show all	503 aa 57.4 kDa	No	0
LRRFIP2-012 ENSP00000409574 ENST00000416425	C9JSU1 [Direct mapping] Leucine-rich repeat flightless-interacting protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		225 aa 26 kDa	No	0
LRRFIP2-017 ENSP00000391360 ENST00000452742	C9J321 [Direct mapping] Leucine-rich repeat flightless-interacting protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.7 kDa	No	0
LRRFIP2-018 ENSP00000416013 ENST00000436858	C9JJC9 [Direct mapping] Leucine-rich repeat flightless-interacting protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.7 kDa	No	0
LRRFIP2-019 ENSP00000416907 ENST00000434749	C9JC17 [Direct mapping] Leucine-rich repeat flightless-interacting protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		59 aa 6.7 kDa	No	0
LRRFIP2-021 ENSP00000412206 ENST00000438374	C9J0U5 [Direct mapping] Leucine-rich repeat flightless-interacting protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		68 aa 7.8 kDa	No	0
LRRFIP2-023 ENSP00000413026 ENST00000440742	H7C3N9 [Direct mapping] Leucine-rich repeat flightless-interacting protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		182 aa 20.9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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