Expression of KRT31 in cancer - Summary - The Human Protein Atlas

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KRT31

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KRT31
Gene description	Keratin 31, type I
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (cervical cancer, endometrial cancer, head and neck cancer, lung cancer, melanoma, urothelial cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly expressed in hair follicle cortex.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Pending external verification. Protein expression in hair follicles can be correlated with GTEx RNA data.
Reliability score	Supported based on 2 antibodies. HPA049550 , HPA055194
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (cervical cancer, endometrial cancer, head and neck cancer, lung cancer, melanoma, urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049550	HPA055194

GENE INFORMATION
Gene name	KRT31 (HGNC Symbol)
Synonyms	Ha-1, KRTHA1
Description	Keratin 31, type I (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	41393724 - 41397592
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000094796 (version 83.38)
Entrez gene	3881
UniProt	Q15323 (UniProt - Evidence at protein level)
neXtProt	NX_Q15323
Antibodypedia	KRT31 antibodies

PROTEIN BROWSER

KRT31-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT31-001 ENSP00000251645 ENST00000251645	Q15323 [Direct mapping] Keratin, type I cuticular Ha1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005882 [intermediate filament] GO:0008544 [epidermis development] GO:0070062 [extracellular exosome] Show all	416 aa 47.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.