Expression of CRAT in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CRAT
Gene description	Carnitine O-acetyltransferase
Protein class	Enzymes Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most cell types, highly abundant in cells in seminiferous tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 3 antibodies. HPA019230 , HPA020260 , HPA022815
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA019230	HPA020260	HPA022815

GENE INFORMATION
Gene name	CRAT (HGNC Symbol)
Synonyms	CAT1
Description	Carnitine O-acetyltransferase (HGNC Symbol)
Entrez gene summary	This gene encodes carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome	9
Cytoband	q34.11
Chromosome location (bp)	129094810 - 129111189
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000095321 (version 83.38)
Entrez gene	1384
UniProt	P43155 (UniProt - Evidence at protein level)
neXtProt	NX_P43155
Antibodypedia	CRAT antibodies

PROTEIN BROWSER

CRAT-004	CRAT-006	CRAT-010	CRAT-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRAT-004 ENSP00000377045 ENST00000393384	A6PVN3 [Direct mapping] Carnitine O-acetyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016746 [transferase activity, transferring acyl groups] Show all	161 aa 18.2 kDa	No	0
CRAT-006 ENSP00000315013 ENST00000318080	P43155 [Direct mapping] Carnitine O-acetyltransferase Show all	Enzymes ENZYME proteins Transferases Transporters Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004092 [carnitine O-acetyltransferase activity] GO:0005102 [receptor binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005777 [peroxisome] GO:0005782 [peroxisomal matrix] GO:0005783 [endoplasmic reticulum] GO:0006810 [transport] GO:0016746 [transferase activity, transferring acyl groups] GO:0019254 [carnitine metabolic process, CoA-linked] GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] Show all	626 aa 70.9 kDa	No	0
CRAT-010 ENSP00000395458 ENST00000455396	H0Y4Z7 [Direct mapping] Carnitine O-acetyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016746 [transferase activity, transferring acyl groups] Show all	201 aa 22.6 kDa	No	0
CRAT-012 ENSP00000390571 ENST00000455830	B7ZBP5 [Direct mapping] Carnitine O-acetyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016746 [transferase activity, transferring acyl groups] Show all	98 aa 11.3 kDa	No	0