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CRAT

GENERAL INFORMATION

Gene name

 CRAT

Gene description

 Carnitine O-acetyltransferase

Protein class

 Enzymes
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most cell types, highly abundant in cells in seminiferous tubules.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA019230 , HPA020260 , HPA022815
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CRAT (HGNC Symbol)

Synonyms

 CAT1

Description

 Carnitine O-acetyltransferase (HGNC Symbol)

Entrez gene summary

 This gene encodes carnitine acetyltransferase (CRAT), which is a key enzyme in the metabolic pathway in mitochondria, peroxisomes and endoplasmic reticulum. CRAT catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acylCoA/CoA in the subcellular compartments. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 129094810 - 129111189

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000095321 (version 83.38)

Entrez gene

 1384

UniProt

 P43155 (UniProt - Evidence at protein level)

neXtProt

 NX_P43155

Antibodypedia

 CRAT antibodies

PROTEIN BROWSER
CRAT-004
CRAT-006
CRAT-010
CRAT-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRAT-004
ENSP00000377045
ENST00000393384
A6PVN3 [Direct mapping]
Carnitine O-acetyltransferase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016746 [transferase activity, transferring acyl groups]
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 161 aa
18.2 kDa 		No 0
CRAT-006
ENSP00000315013
ENST00000318080
P43155 [Direct mapping]
Carnitine O-acetyltransferase
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Enzymes
   ENZYME proteins
   Transferases
Transporters
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004092 [carnitine O-acetyltransferase activity]
GO:0005102 [receptor binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005777 [peroxisome]
GO:0005782 [peroxisomal matrix]
GO:0005783 [endoplasmic reticulum]
GO:0006810 [transport]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0019254 [carnitine metabolic process, CoA-linked]
GO:0033540 [fatty acid beta-oxidation using acyl-CoA oxidase]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
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 626 aa
70.9 kDa 		No 0
CRAT-010
ENSP00000395458
ENST00000455396
H0Y4Z7 [Direct mapping]
Carnitine O-acetyltransferase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016746 [transferase activity, transferring acyl groups]
Show all
 201 aa
22.6 kDa 		No 0
CRAT-012
ENSP00000390571
ENST00000455830
B7ZBP5 [Direct mapping]
Carnitine O-acetyltransferase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016746 [transferase activity, transferring acyl groups]
Show all
 98 aa
11.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.