Expression of BTAF1 in cancer - Summary - The Human Protein Atlas

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BTAF1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	BTAF1
Gene description	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and head and neck cancer (favourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	BTAF1 (HGNC Symbol)
Synonyms	MOT1, TAF(II)170, TAF-172, TAF172, TAFII170
Description	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (HGNC Symbol)
Entrez gene summary	This gene encodes a TAF (TATA box-binding protein-associated factor), which associates with TBP (TATA box-binding protein) to form the B-TFIID complex that is required for transcription initiation of genes by RNA polymerase II. This TAF has DNA-dependent ATPase activity, which drives the dissociation of TBP from DNA, freeing the TBP to associate with other TATA boxes or TATA-less promoters. [provided by RefSeq, Sep 2011]
Chromosome	10
Cytoband	q23.32
Chromosome location (bp)	91923769 - 92030325
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000095564 (version 83.38)
Entrez gene	9044
UniProt	O14981 (UniProt - Evidence at protein level)
neXtProt	NX_O14981
Antibodypedia	BTAF1 antibodies

PROTEIN BROWSER

BTAF1-001	BTAF1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BTAF1-001 ENSP00000265990 ENST00000265990	O14981 [Direct mapping] TATA-binding protein-associated factor 172 Q2M1V9 [Target identity:100%; Query identity:100%] BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa; BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae), isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004386 [helicase activity] GO:0005488 [binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0008152 [metabolic process] GO:0035562 [negative regulation of chromatin binding] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	1849 aa 206.9 kDa	No	0
BTAF1-201 ENSP00000439924 ENST00000544642	A0A0A0MTH9 [Direct mapping] TATA-binding protein-associated factor 172 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005524 [ATP binding] Show all	1849 aa 206.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.