Fields »
ABOUT
HELP
BLOG
BLNK

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 BLNK

Gene description

 B-cell linker

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the nucleoplasm.

RNA cell category

 Group enriched (U-698, REH, RPMI-8226, Daudi)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (supported)

Additional location

 In addition localized to the Nucleoplasm (uncertain)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB016291
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (U-698, REH, RPMI-8226, Daudi)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the nucleoplasm.

Main location

 Cytosol (supported)

Additional location

 Nucleoplasm (uncertain)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB016291 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 BLNK (HGNC Symbol)

Synonyms

 BASH, bca, BLNK-s, Ly57, SLP-65, SLP65

Description

 B-cell linker (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

Chromosome

 10

Cytoband

 q24.1

Chromosome location (bp)

 96191702 - 96271587

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000095585 (version 83.38)

Entrez gene

 29760

UniProt

 Q8WV28 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WV28

Antibodypedia

 BLNK antibodies

PROTEIN BROWSER
BLNK-001
BLNK-002
BLNK-003
BLNK-201
BLNK-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BLNK-001
ENSP00000224337
ENST00000224337
Q8WV28 [Direct mapping]
B-cell linker protein
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0006959 [humoral immune response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0030183 [B cell differentiation]
GO:0035556 [intracellular signal transduction]
Show all
 456 aa
50.5 kDa 		No 0
BLNK-002
ENSP00000360218
ENST00000371176
Q8WV28 [Direct mapping]
B-cell linker protein
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0006959 [humoral immune response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0030183 [B cell differentiation]
GO:0035556 [intracellular signal transduction]
Show all
 433 aa
48.2 kDa 		No 0
BLNK-003
ENSP00000465741
ENST00000495266
K7EKR2 [Direct mapping]
B-cell linker protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 65 aa
7.4 kDa 		No 0
BLNK-201
ENSP00000397487
ENST00000413476
Q8WV28 [Direct mapping]
B-cell linker protein
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005070 [SH3/SH2 adaptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006954 [inflammatory response]
GO:0006959 [humoral immune response]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0009967 [positive regulation of signal transduction]
GO:0030183 [B cell differentiation]
GO:0035556 [intracellular signal transduction]
Show all
 404 aa
44.5 kDa 		No 0
BLNK-202
ENSP00000391924
ENST00000427367
Q2MD59 [Direct mapping]
B-cell linker protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
Show all
 299 aa
33 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.