Expression of BLNK in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	BLNK
Gene description	B-cell linker
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (Daudi, REH, RPMI-8226, U-698)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in lymphoid tissues. Lower expression observed in several other tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 4 antibodies. HPA038309 , HPA038310 , CAB009333 , CAB016291
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA038309	HPA038310	CAB009333	CAB016291

GENE INFORMATION
Gene name	BLNK (HGNC Symbol)
Synonyms	BASH, bca, BLNK-s, Ly57, SLP-65, SLP65
Description	B-cell linker (HGNC Symbol)
Entrez gene summary	This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]
Chromosome	10
Cytoband	q24.1
Chromosome location (bp)	96191702 - 96271587
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000095585 (version 83.38)
Entrez gene	29760
UniProt	Q8WV28 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WV28
Antibodypedia	BLNK antibodies

PROTEIN BROWSER

BLNK-001	BLNK-002	BLNK-003	BLNK-201	BLNK-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BLNK-001 ENSP00000224337 ENST00000224337	Q8WV28 [Direct mapping] B-cell linker protein Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006959 [humoral immune response] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0009967 [positive regulation of signal transduction] GO:0030183 [B cell differentiation] GO:0035556 [intracellular signal transduction] Show all	456 aa 50.5 kDa	No	0
BLNK-002 ENSP00000360218 ENST00000371176	Q8WV28 [Direct mapping] B-cell linker protein Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006959 [humoral immune response] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0009967 [positive regulation of signal transduction] GO:0030183 [B cell differentiation] GO:0035556 [intracellular signal transduction] Show all	433 aa 48.2 kDa	No	0
BLNK-003 ENSP00000465741 ENST00000495266	K7EKR2 [Direct mapping] B-cell linker protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	65 aa 7.4 kDa	No	0
BLNK-201 ENSP00000397487 ENST00000413476	Q8WV28 [Direct mapping] B-cell linker protein Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006954 [inflammatory response] GO:0006959 [humoral immune response] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0009967 [positive regulation of signal transduction] GO:0030183 [B cell differentiation] GO:0035556 [intracellular signal transduction] Show all	404 aa 44.5 kDa	No	0
BLNK-202 ENSP00000391924 ENST00000427367	Q2MD59 [Direct mapping] B-cell linker protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	299 aa 33 kDa	No	0