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TLL2

GENERAL INFORMATION

Gene name

 TLL2

Gene description

 Tolloid-like 2

Protein class

 Enzymes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (RPTEC TERT1)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 TLL2

Synonyms

Description

 Tolloid-like 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q24.1

Chromosome location (bp)

 96364606 - 96513918

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000095587 (version 83.38)

Entrez gene

 7093

UniProt

 Q9Y6L7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6L7

Antibodypedia

 TLL2 antibodies

PROTEIN BROWSER
TLL2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TLL2-001
ENSP00000350630
ENST00000357947
Q9Y6L7 [Direct mapping]
Tolloid-like protein 2
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Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
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GO:0004222 [metalloendopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006508 [proteolysis]
GO:0007275 [multicellular organismal development]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0022617 [extracellular matrix disassembly]
GO:0030154 [cell differentiation]
GO:0030198 [extracellular matrix organization]
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 1015 aa
113.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.