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HIVEP1

GENERAL INFORMATION

Gene name

 HIVEP1

Gene description

 Human immunodeficiency virus type I enhancer binding protein 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA050724
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HIVEP1 (HGNC Symbol)

Synonyms

 CIRIP, CRYBP1, MBP-1, PRDII-BF1, Schnurri-1, ZAS1, ZNF40, ZNF40A

Description

 Human immunodeficiency virus type I enhancer binding protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a transcription factor belonging to the ZAS family, members of which are large proteins that contain a ZAS domain - a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine-rich sequence. These proteins bind specifically to the DNA sequence motif, GGGACTTTCC, found in the enhancer elements of several viral promoters, including human immunodeficiency virus (HIV), and to related sequences found in the enhancer elements of a number of cellular promoters. This protein binds to this sequence motif, suggesting a role in the transcriptional regulation of both viral and cellular genes. [provided by RefSeq, Oct 2011]

Chromosome

 6

Cytoband

 p24.1

Chromosome location (bp)

 12008762 - 12164999

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000095951 (version 83.38)

Entrez gene

 3096

UniProt

 P15822 (UniProt - Evidence at protein level)

neXtProt

 NX_P15822

Antibodypedia

 HIVEP1 antibodies

PROTEIN BROWSER
HIVEP1-001
HIVEP1-002
HIVEP1-004
HIVEP1-005
HIVEP1-006
HIVEP1-007
HIVEP1-201
HIVEP1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HIVEP1-001
ENSP00000368698
ENST00000379388
P15822 [Direct mapping]
Zinc finger protein 40
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001206 [transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007275 [multicellular organismal development]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046872 [metal ion binding]
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 2718 aa
296.8 kDa 		No 0
HIVEP1-002
ENSP00000409078
ENST00000442081
C9JLG1 [Direct mapping]
Zinc finger protein 40
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
Show all
 240 aa
26.5 kDa 		No 0
HIVEP1-004
ENSP00000419762
ENST00000491710
C9JZF8 [Direct mapping]
Zinc finger protein 40
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 120 aa
13.5 kDa 		No 0
HIVEP1-005
ENSP00000417348
ENST00000487103
C9J2N3 [Direct mapping]
Zinc finger protein 40
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 142 aa
15.9 kDa 		No 0
HIVEP1-006
ENSP00000418021
ENST00000478545
C9JAW2 [Direct mapping]
Zinc finger protein 40
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 128 aa
14.3 kDa 		No 0
HIVEP1-007
ENSP00000419721
ENST00000484210
C9JZV1 [Direct mapping]
Zinc finger protein 40
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 47 aa
5.2 kDa 		No 0
HIVEP1-201
ENSP00000445617
ENST00000541134
F5H212 [Direct mapping]
Zinc finger protein 40
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
Show all
 2717 aa
296.7 kDa 		No 0
HIVEP1-202
ENSP00000486543
ENST00000627968
A0A0D9SFF3 [Direct mapping]
Zinc finger protein 40
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
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 583 aa
62.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.