Cell atlas - FKBP5 - The Human Protein Atlas

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FKBP5

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	FKBP5
Gene description	FK506 binding protein 5
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Cell line enhanced (ASC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by custom assay
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. CAB009315 , HPA031093
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA031093	A-431	Nucleoplasm
HPA031093	HEK 293	Nucleoplasm	Intensity
HPA031093	U-2 OS	Nucleoplasm	Intensity	Intensity
CAB009315	A-431	Nucleoplasm
CAB009315	U-2 OS	Nucleoplasm	Intensity
CAB009315	U-251 MG	Nucleoplasm
CAB009315	U-251 MG	Nucleoli fibrillar center

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA031093	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. FKBP5 is mostly expressed at the G1/S checkpoint, and during S and/or G2.

CELL CYCLE
Summary	Expression has cell cycle dependency according to custom assay
Intensity variation	Nucleoplasm

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000024222 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA031093	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	FKBP5 (HGNC Symbol)
Synonyms	FKBP51, FKBP54, P54, PPIase, Ptg-10
Description	FK506 binding protein 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Chromosome	6
Cytoband	p21.31
Chromosome location (bp)	35573585 - 35728583
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000096060 (version 83.38)
Entrez gene	2289
UniProt	Q13451 (UniProt - Evidence at protein level)
neXtProt	NX_Q13451
Antibodypedia	FKBP5 antibodies

PROTEIN BROWSER

FKBP5-001	FKBP5-201	FKBP5-202	FKBP5-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FKBP5-001 ENSP00000349811 ENST00000357266	Q13451 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP5 Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0016020 [membrane] GO:0031072 [heat shock protein binding] GO:0061077 [chaperone-mediated protein folding] GO:0070062 [extracellular exosome] Show all	457 aa 51.2 kDa	No	0
FKBP5-201 ENSP00000444810 ENST00000536438	Q13451 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP5 Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0016020 [membrane] GO:0031072 [heat shock protein binding] GO:0061077 [chaperone-mediated protein folding] GO:0070062 [extracellular exosome] Show all	457 aa 51.2 kDa	No	0
FKBP5-202 ENSP00000441205 ENST00000539068	Q13451 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP5 Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0016020 [membrane] GO:0031072 [heat shock protein binding] GO:0061077 [chaperone-mediated protein folding] GO:0070062 [extracellular exosome] Show all	457 aa 51.2 kDa	No	0
FKBP5-203 ENSP00000442340 ENST00000542713	Q13451 [Direct mapping] Peptidyl-prolyl cis-trans isomerase FKBP5 Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000413 [protein peptidyl-prolyl isomerization] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005528 [FK506 binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0016020 [membrane] GO:0031072 [heat shock protein binding] GO:0061077 [chaperone-mediated protein folding] GO:0070062 [extracellular exosome] Show all	268 aa 30 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.