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FKBP5

GENERAL INFORMATION

Gene name

 FKBP5

Gene description

 FK506 binding protein 5

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression combined with lower cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA031092 , HPA031093 , HPA031095 , CAB009315
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA031092
HPA031093
HPA031095
CAB009315

GENE INFORMATION

Gene name

 FKBP5 (HGNC Symbol)

Synonyms

 FKBP51, FKBP54, P54, PPIase, Ptg-10

Description

 FK506 binding protein 5 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Chromosome

 6

Cytoband

 p21.31

Chromosome location (bp)

 35573585 - 35728583

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000096060 (version 83.38)

Entrez gene

 2289

UniProt

 Q13451 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13451

Antibodypedia

 FKBP5 antibodies

PROTEIN BROWSER
FKBP5-001
FKBP5-201
FKBP5-202
FKBP5-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FKBP5-001
ENSP00000349811
ENST00000357266
Q13451 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP5
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Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0016020 [membrane]
GO:0031072 [heat shock protein binding]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
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 457 aa
51.2 kDa 		No 0
FKBP5-201
ENSP00000444810
ENST00000536438
Q13451 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP5
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Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0016020 [membrane]
GO:0031072 [heat shock protein binding]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
Show all
 457 aa
51.2 kDa 		No 0
FKBP5-202
ENSP00000441205
ENST00000539068
Q13451 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP5
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0016020 [membrane]
GO:0031072 [heat shock protein binding]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
Show all
 457 aa
51.2 kDa 		No 0
FKBP5-203
ENSP00000442340
ENST00000542713
Q13451 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP5
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0016020 [membrane]
GO:0031072 [heat shock protein binding]
GO:0061077 [chaperone-mediated protein folding]
GO:0070062 [extracellular exosome]
Show all
 268 aa
30 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.