Expression of MLN in cancer - Summary - The Human Protein Atlas

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MLN

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MLN
Gene description	Motilin
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (testis cancer)
HPA (cell line):	Cell line enhanced (CACO-2, TIME)
HPA (normal tissue):	Tissue enriched (duodenum)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in a subset of cells in small intestine.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA069392
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA069392

GENE INFORMATION
Gene name	MLN
Synonyms
Description	Motilin (HGNC Symbol)
Entrez gene summary	This gene encodes a small peptide hormone that is secreted by cells of the small intestine to regulate gastrointestinal contractions and motility. Proteolytic processing of the secreted protein produces the mature peptide and a byproduct referred to as motilin-associated peptide (MAP). Three transcript variants encoding different preproprotein isoforms but the same mature peptide have been found for this gene. [provided by RefSeq, May 2010]
Chromosome	6
Cytoband	p21.31
Chromosome location (bp)	33794673 - 33804011
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000096395 (version 83.38)
Entrez gene	4295
UniProt	P12872 (UniProt - Evidence at protein level)
neXtProt	NX_P12872
Antibodypedia	MLN antibodies

PROTEIN BROWSER

MLN-001	MLN-002	MLN-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MLN-001 ENSP00000388825 ENST00000430124	P12872 [Direct mapping] Promotilin Motilin Motilin-associated peptide Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005102 [receptor binding] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] Show all	115 aa 12.9 kDa	Yes	0
MLN-002 ENSP00000425467 ENST00000507738	P12872 [Direct mapping] Promotilin Motilin Motilin-associated peptide Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005102 [receptor binding] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] Show all	108 aa 12.1 kDa	Yes	0
MLN-003 ENSP00000266003 ENST00000266003	P12872 [Direct mapping] Promotilin Motilin Motilin-associated peptide Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005102 [receptor binding] GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007267 [cell-cell signaling] Show all	114 aa 12.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.