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CDC5L

GENERAL INFORMATION

Gene name

 CDC5L

Gene description

 Cell division cycle 5-like

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA006302 , HPA011361 , CAB012275
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CDC5L (HGNC Symbol)

Synonyms

 CDC5, CEF1, hCDC5, PCDC5RP

Description

 Cell division cycle 5-like (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.1

Chromosome location (bp)

 44387525 - 44450426

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000096401 (version 83.38)

Entrez gene

 988

UniProt

 Q99459 (UniProt - Evidence at protein level)

neXtProt

 NX_Q99459

Antibodypedia

 CDC5L antibodies

PROTEIN BROWSER
CDC5L-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC5L-001
ENSP00000360532
ENST00000371477
Q99459 [Direct mapping]
Cell division cycle 5-like protein
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Predicted intracellular proteins
Plasma proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000974 [Prp19 complex]
GO:0001222 [transcription corepressor binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005662 [DNA replication factor A complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008157 [protein phosphatase 1 binding]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016607 [nuclear speck]
GO:0019901 [protein kinase binding]
GO:0032993 [protein-DNA complex]
GO:0043522 [leucine zipper domain binding]
GO:0044344 [cellular response to fibroblast growth factor stimulus]
GO:0044822 [poly(A) RNA binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0071013 [catalytic step 2 spliceosome]
GO:0071352 [cellular response to interleukin-2]
GO:0071987 [WD40-repeat domain binding]
GO:0072422 [signal transduction involved in DNA damage checkpoint]
GO:1904568 [cellular response to wortmannin]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990646 [cellular response to prolactin]
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 802 aa
92.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.