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Weak to moderate cytoplasmic and/or membranous staining was observed in several skin, urothelial, colorectal, breast and stomach cancers along with few ovarian, lung and pancreatic cancers. Thyroid cancers showed moderate to strong positivity. Remaining cancer tissues were negative.
Hepatocellular carcinomas along with few cases of skin and renal cancer showed weak to moderate cytoplasmic immunoreactivity. Remaining cancer tissues were in general negative.
Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]