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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

DSP

Gene description

Desmoplakin

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Cell line enhanced (BEWO, HaCaT, hTCEpi)
HPA (normal tissue):Group enriched (esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression most abundant in squamous epithelia and intercalated discs.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA045840 , HPA054950 , CAB037324
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable) and urothelial cancer (unfavourable).
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 910111213141516 Renal cancer p<0.001
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 910111213 Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)
0.02004006008001.0k1.2k1.4kFPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA045840
HPA054950
CAB037324

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic and/or membranous staining was observed in several skin, urothelial, colorectal, breast and stomach cancers along with few ovarian, lung and pancreatic cancers. Thyroid cancers showed moderate to strong positivity. Remaining cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Hepatocellular carcinomas along with few cases of skin and renal cancer showed weak to moderate cytoplasmic immunoreactivity. Remaining cancer tissues were in general negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues were generally negative.

GENE INFORMATION

Gene name

DSP (HGNC Symbol)

Synonyms

DPI, DPII, KPPS2, PPKS2

Description

Desmoplakin (HGNC Symbol)

Entrez gene summary

Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p24.3

Chromosome location (bp)

7541575 - 7586717

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000096696 (version 83.38)

Entrez gene

1832

UniProt

P15924 (UniProt - Evidence at protein level)

neXtProt

NX_P15924

Antibodypedia

DSP antibodies

PROTEIN BROWSER

DSP-001
DSP-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DSP-001
ENSP00000369129
ENST00000379802
P15924 [Direct mapping]
Desmoplakin
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001533 [cornified envelope]
GO:0002934 [desmosome organization]
GO:0003223 [ventricular compact myocardium morphogenesis]
GO:0005080 [protein kinase C binding]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005916 [fascia adherens]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008544 [epidermis development]
GO:0012501 [programmed cell death]
GO:0014704 [intercalated disc]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018149 [peptide cross-linking]
GO:0030057 [desmosome]
GO:0030216 [keratinocyte differentiation]
GO:0030674 [protein binding, bridging]
GO:0034332 [adherens junction organization]
GO:0042060 [wound healing]
GO:0043588 [skin development]
GO:0044822 [poly(A) RNA binding]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0045109 [intermediate filament organization]
GO:0050839 [cell adhesion molecule binding]
GO:0070062 [extracellular exosome]
GO:0071896 [protein localization to adherens junction]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0097110 [scaffold protein binding]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
Show all
2871 aa
331.8 kDa
No 0
DSP-002
ENSP00000396591
ENST00000418664
P15924 [Direct mapping]
Desmoplakin
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001533 [cornified envelope]
GO:0002934 [desmosome organization]
GO:0003223 [ventricular compact myocardium morphogenesis]
GO:0005080 [protein kinase C binding]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008544 [epidermis development]
GO:0012501 [programmed cell death]
GO:0014704 [intercalated disc]
GO:0018149 [peptide cross-linking]
GO:0030057 [desmosome]
GO:0030216 [keratinocyte differentiation]
GO:0030674 [protein binding, bridging]
GO:0044822 [poly(A) RNA binding]
GO:0045109 [intermediate filament organization]
GO:0050839 [cell adhesion molecule binding]
GO:0070062 [extracellular exosome]
GO:0071896 [protein localization to adherens junction]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0097110 [scaffold protein binding]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
Show all
2272 aa
260.1 kDa
No 0

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