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DSP

GENERAL INFORMATION

Gene name

 DSP

Gene description

 Desmoplakin

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (esophagus, skin)
GTEx:Tissue enhanced (esophagus, skin)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression most abundant in squamous epithelia and intercalated discs.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA045840 , HPA054950 , CAB037324
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, skin)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin02004006008001,0001,200TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus, skin)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0100200300400500600RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina02004006008001,0001,200Tags Per Million

GENE INFORMATION

Gene name

 DSP (HGNC Symbol)

Synonyms

 DPI, DPII, KPPS2, PPKS2

Description

 Desmoplakin (HGNC Symbol)

Entrez gene summary

 Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p24.3

Chromosome location (bp)

 7541575 - 7586717

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000096696 (version 83.38)

Entrez gene

 1832

UniProt

 P15924 (UniProt - Evidence at protein level)

neXtProt

 NX_P15924

Antibodypedia

 DSP antibodies

PROTEIN BROWSER
DSP-001
DSP-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DSP-001
ENSP00000369129
ENST00000379802
P15924 [Direct mapping]
Desmoplakin
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001533 [cornified envelope]
GO:0002934 [desmosome organization]
GO:0003223 [ventricular compact myocardium morphogenesis]
GO:0005080 [protein kinase C binding]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005916 [fascia adherens]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008544 [epidermis development]
GO:0012501 [programmed cell death]
GO:0014704 [intercalated disc]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018149 [peptide cross-linking]
GO:0030057 [desmosome]
GO:0030216 [keratinocyte differentiation]
GO:0030674 [protein binding, bridging]
GO:0034332 [adherens junction organization]
GO:0042060 [wound healing]
GO:0043588 [skin development]
GO:0044822 [poly(A) RNA binding]
GO:0045104 [intermediate filament cytoskeleton organization]
GO:0045109 [intermediate filament organization]
GO:0050839 [cell adhesion molecule binding]
GO:0070062 [extracellular exosome]
GO:0071896 [protein localization to adherens junction]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0097110 [scaffold protein binding]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
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 2871 aa
331.8 kDa 		No 0
DSP-002
ENSP00000396591
ENST00000418664
P15924 [Direct mapping]
Desmoplakin
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001533 [cornified envelope]
GO:0002934 [desmosome organization]
GO:0003223 [ventricular compact myocardium morphogenesis]
GO:0005080 [protein kinase C binding]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0008544 [epidermis development]
GO:0012501 [programmed cell death]
GO:0014704 [intercalated disc]
GO:0018149 [peptide cross-linking]
GO:0030057 [desmosome]
GO:0030216 [keratinocyte differentiation]
GO:0030674 [protein binding, bridging]
GO:0044822 [poly(A) RNA binding]
GO:0045109 [intermediate filament organization]
GO:0050839 [cell adhesion molecule binding]
GO:0070062 [extracellular exosome]
GO:0071896 [protein localization to adherens junction]
GO:0086073 [bundle of His cell-Purkinje myocyte adhesion involved in cell communication]
GO:0086083 [cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0097110 [scaffold protein binding]
GO:0098911 [regulation of ventricular cardiac muscle cell action potential]
Show all
 2272 aa
260.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.