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HNRNPH3

GENERAL INFORMATION

Gene name

 HNRNPH3

Gene description

 Heterogeneous nuclear ribonucleoprotein H3 (2H9)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 HNRNPH3 (HGNC Symbol)

Synonyms

 2H9, HNRPH3

Description

 Heterogeneous nuclear ribonucleoprotein H3 (2H9) (HGNC Symbol)

Entrez gene summary

 This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is localized in nuclear bodies of the nucleus. This protein is involved in the splicing process and it also participates in early heat shock-induced splicing arrest by transiently leaving the hnRNP complexes. Several alternatively spliced transcript variants have been noted for this gene, however, not all are fully characterized. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q21.3

Chromosome location (bp)

 68331174 - 68343191

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000096746 (version 83.38)

Entrez gene

 3189

UniProt

 P31942 (UniProt - Evidence at protein level)

neXtProt

 NX_P31942

Antibodypedia

 HNRNPH3 antibodies

PROTEIN BROWSER
HNRNPH3-003
HNRNPH3-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HNRNPH3-003
ENSP00000346726
ENST00000354695
P31942 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein H3
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0006396 [RNA processing]
GO:0008380 [RNA splicing]
GO:0030855 [epithelial cell differentiation]
GO:0044822 [poly(A) RNA binding]
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 331 aa
35.2 kDa 		No 0
HNRNPH3-012
ENSP00000265866
ENST00000265866
P31942 [Direct mapping]
Heterogeneous nuclear ribonucleoprotein H3
A0A024QZK8 [Target identity:100%; Query identity:100%]
Heterogeneous nuclear ribonucleoprotein H3 (2H9), isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0006396 [RNA processing]
GO:0008380 [RNA splicing]
GO:0030855 [epithelial cell differentiation]
GO:0044822 [poly(A) RNA binding]
Show all
 346 aa
36.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.