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HCN2

GENERAL INFORMATION

Gene name

 HCN2

Gene description

 Hyperpolarization activated cyclic nucleotide gated potassium channel 2

Protein class

 Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (glioma, melanoma, renal cancer, testis cancer)
HPA (cell line):Cell line enhanced (A549, MCF7, U-87 MG)
HPA (normal tissue):Group enriched (cerebral cortex, heart muscle)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (glioma, melanoma, renal cancer, testis cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 HCN2 (HGNC Symbol)

Synonyms

 BCNG-2, BCNG2, HAC-1

Description

 Hyperpolarization activated cyclic nucleotide gated potassium channel 2 (HGNC Symbol)

Entrez gene summary

 Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 589893 - 617159

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099822 (version 83.38)

Entrez gene

 610

UniProt

 Q9UL51 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UL51

Antibodypedia

 HCN2 antibodies

PROTEIN BROWSER
HCN2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HCN2-001
ENSP00000251287
ENST00000251287
Q9UL51 [Direct mapping]
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
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Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Cyclic Nucleotide-Regulated Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0005216 [ion channel activity]
GO:0005222 [intracellular cAMP activated cation channel activity]
GO:0005248 [voltage-gated sodium channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0007267 [cell-cell signaling]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0030552 [cAMP binding]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0042802 [identical protein binding]
GO:0055085 [transmembrane transport]
GO:0071320 [cellular response to cAMP]
GO:0071321 [cellular response to cGMP]
GO:0071805 [potassium ion transmembrane transport]
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 889 aa
96.9 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.