Tissue expression of HCN2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HCN2
Gene description	Hyperpolarization activated cyclic nucleotide gated potassium channel 2
Protein class	Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (cerebral cortex, heart muscle)
GTEx:	Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5:	Group enriched (brain, caudate, cerebellum, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (cerebral cortex, heart muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, cerebellum, cerebral cortex, hippocampus, hypothalamus, pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus)

GENE INFORMATION
Gene name	HCN2 (HGNC Symbol)
Synonyms	BCNG-2, BCNG2, HAC-1
Description	Hyperpolarization activated cyclic nucleotide gated potassium channel 2 (HGNC Symbol)
Entrez gene summary	Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	589893 - 617159
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099822 (version 83.38)
Entrez gene	610
UniProt	Q9UL51 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UL51
Antibodypedia	HCN2 antibodies

PROTEIN BROWSER

HCN2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HCN2-001 ENSP00000251287 ENST00000251287	Q9UL51 [Direct mapping] Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Cyclic Nucleotide-Regulated Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005222 [intracellular cAMP activated cation channel activity] GO:0005248 [voltage-gated sodium channel activity] GO:0005249 [voltage-gated potassium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0007267 [cell-cell signaling] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0016020 [membrane] GO:0030552 [cAMP binding] GO:0034765 [regulation of ion transmembrane transport] GO:0035725 [sodium ion transmembrane transport] GO:0042391 [regulation of membrane potential] GO:0042802 [identical protein binding] GO:0055085 [transmembrane transport] GO:0071320 [cellular response to cAMP] GO:0071321 [cellular response to cGMP] GO:0071805 [potassium ion transmembrane transport] Show all	889 aa 96.9 kDa	No	6