Expression of CDHR5 in cancer - Summary

GENERAL INFORMATION
Gene name	CDHR5
Gene description	Cadherin-related family member 5
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (colorectal cancer, liver cancer, pancreatic cancer, renal cancer, stomach cancer)
HPA (cell line):	Cell line enhanced (CACO-2)
HPA (normal tissue):	Group enriched (colon, duodenum, kidney, liver, rectum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in luminal membranes of intestine, gallbladder, renal tubules and epididymis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA009081 , HPA009173 , CAB025004
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (colorectal cancer, liver cancer, pancreatic cancer, renal cancer, stomach cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA009081	HPA009173	CAB025004

GENE INFORMATION
Gene name	CDHR5 (HGNC Symbol)
Synonyms	FLJ20219, MU-PCDH, MUCDHL, MUPCDH
Description	Cadherin-related family member 5 (HGNC Symbol)
Entrez gene summary	This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2010]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	616565 - 626078
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099834 (version 83.38)
Entrez gene	53841
UniProt	Q9HBB8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HBB8
Antibodypedia	CDHR5 antibodies

PROTEIN BROWSER

CDHR5-001	CDHR5-002	CDHR5-006	CDHR5-007	CDHR5-008	CDHR5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDHR5-001 ENSP00000351118 ENST00000358353	Q9HBB8 [Direct mapping] Cadherin-related family member 5 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005905 [coated pit] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0008013 [beta-catenin binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	845 aa 88.2 kDa	Yes	0
CDHR5-002 ENSP00000345726 ENST00000349570	Q9HBB8 [Direct mapping] Cadherin-related family member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0008013 [beta-catenin binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	651 aa 69.6 kDa	Yes	1
CDHR5-006 ENSP00000431505 ENST00000531088	E9PKR2 [Direct mapping] Cadherin-related family member 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		15 aa 1.6 kDa	No	0
CDHR5-007 ENSP00000436295 ENST00000534311	E9PPW2 [Direct mapping] Cadherin-related family member 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		166 aa 18.6 kDa	Yes	0
CDHR5-008 ENSP00000435082 ENST00000526077	E9PLX6 [Direct mapping] Cadherin-related family member 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		190 aa 21.1 kDa	Yes	0
CDHR5-201 ENSP00000380676 ENST00000397542	Q9HBB8 [Direct mapping] Cadherin-related family member 5 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0008013 [beta-catenin binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	845 aa 88.2 kDa	Yes	0