Tissue expression of CDHR5 - Summary - The Human Protein Atlas

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CDHR5

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	CDHR5
Gene description	Cadherin-related family member 5
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (colon, duodenum, kidney, liver, rectum, small intestine)
GTEx:	Tissue enriched (small intestine)
FANTOM5:	Group enriched (colon, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Selective expression in luminal membranes of intestine, gallbladder, renal tubules and epididymis.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA009081 , HPA009173 , CAB025004
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (colon, duodenum, kidney, liver, rectum, small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (colon, small intestine)

GENE INFORMATION
Gene name	CDHR5 (HGNC Symbol)
Synonyms	FLJ20219, MU-PCDH, MUCDHL, MUPCDH
Description	Cadherin-related family member 5 (HGNC Symbol)
Entrez gene summary	This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2010]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	616565 - 626078
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000099834 (version 83.38)
Entrez gene	53841
UniProt	Q9HBB8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HBB8
Antibodypedia	CDHR5 antibodies

PROTEIN BROWSER

CDHR5-001	CDHR5-002	CDHR5-006	CDHR5-007	CDHR5-008	CDHR5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDHR5-001 ENSP00000351118 ENST00000358353	Q9HBB8 [Direct mapping] Cadherin-related family member 5 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005905 [coated pit] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0008013 [beta-catenin binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	845 aa 88.2 kDa	Yes	0
CDHR5-002 ENSP00000345726 ENST00000349570	Q9HBB8 [Direct mapping] Cadherin-related family member 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0008013 [beta-catenin binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	651 aa 69.6 kDa	Yes	1
CDHR5-006 ENSP00000431505 ENST00000531088	E9PKR2 [Direct mapping] Cadherin-related family member 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		15 aa 1.6 kDa	No	0
CDHR5-007 ENSP00000436295 ENST00000534311	E9PPW2 [Direct mapping] Cadherin-related family member 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		166 aa 18.6 kDa	Yes	0
CDHR5-008 ENSP00000435082 ENST00000526077	E9PLX6 [Direct mapping] Cadherin-related family member 5 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		190 aa 21.1 kDa	Yes	0
CDHR5-201 ENSP00000380676 ENST00000397542	Q9HBB8 [Direct mapping] Cadherin-related family member 5 Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0008013 [beta-catenin binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	845 aa 88.2 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.