Cell atlas - SPECC1L - The Human Protein Atlas

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SPECC1L

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Actin filaments

Human cell
	Actin Filaments

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GENERAL INFORMATION
Gene name	SPECC1L
Gene description	Sperm antigen with calponin homology and coiled-coil domains 1-like
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the actin filaments.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Actin filaments (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA070614
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the actin filaments.

Main location

Actin filaments (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA070614	BJ	Cytosol
	HPA070614	SiHa	Actin filaments
	HPA070614	U-2 OS	Actin filaments

GENE INFORMATION
Gene name	SPECC1L (HGNC Symbol)
Synonyms	CYTSA, KIAA0376
Description	Sperm antigen with calponin homology and coiled-coil domains 1-like (HGNC Symbol)
Entrez gene summary	This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
Chromosome	22
Cytoband	q11.23
Chromosome location (bp)	24270817 - 24417740
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100014 (version 83.38)
Entrez gene	23384
UniProt	Q69YQ0 (UniProt - Evidence at protein level)
neXtProt	NX_Q69YQ0
Antibodypedia	SPECC1L antibodies

PROTEIN BROWSER

SPECC1L-001	SPECC1L-002	SPECC1L-003	SPECC1L-006	SPECC1L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPECC1L-001 ENSP00000325785 ENST00000314328	Q69YQ0 [Direct mapping] Cytospin-A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005921 [gap junction] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0051301 [cell division] Show all	1117 aa 124.5 kDa	No	0
SPECC1L-002 ENSP00000405671 ENST00000421374	C9J8U1 [Direct mapping] Cytospin-A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		789 aa 88.3 kDa	No	0
SPECC1L-003 ENSP00000414354 ENST00000440893	C9JLY8 [Direct mapping] Cytospin-A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		175 aa 18.9 kDa	No	0
SPECC1L-006 ENSP00000439633 ENST00000541492	Q69YQ0 [Direct mapping] Cytospin-A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005921 [gap junction] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0051301 [cell division] Show all	1078 aa 120.1 kDa	No	0
SPECC1L-201 ENSP00000393363 ENST00000437398	Q69YQ0 [Direct mapping] Cytospin-A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005921 [gap junction] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0051301 [cell division] Show all	1117 aa 124.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.