Expression of SPECC1L in cancer - Summary - The Human Protein Atlas

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SPECC1L

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SPECC1L
Gene description	Sperm antigen with calponin homology and coiled-coil domains 1-like
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA070614
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA070614

GENE INFORMATION
Gene name	SPECC1L (HGNC Symbol)
Synonyms	CYTSA, KIAA0376
Description	Sperm antigen with calponin homology and coiled-coil domains 1-like (HGNC Symbol)
Entrez gene summary	This gene encodes a coiled-coil domain containing protein. The encoded protein may play a critical role in actin-cytoskeletal reorganization during facial morphogenesis. Mutations in this gene are a cause of oblique facial clefting-1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A read-through transcript composed of SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and the downstream ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
Chromosome	22
Cytoband	q11.23
Chromosome location (bp)	24270817 - 24417740
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100014 (version 83.38)
Entrez gene	23384
UniProt	Q69YQ0 (UniProt - Evidence at protein level)
neXtProt	NX_Q69YQ0
Antibodypedia	SPECC1L antibodies

PROTEIN BROWSER

SPECC1L-001	SPECC1L-002	SPECC1L-003	SPECC1L-006	SPECC1L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPECC1L-001 ENSP00000325785 ENST00000314328	Q69YQ0 [Direct mapping] Cytospin-A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005921 [gap junction] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0051301 [cell division] Show all	1117 aa 124.5 kDa	No	0
SPECC1L-002 ENSP00000405671 ENST00000421374	C9J8U1 [Direct mapping] Cytospin-A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		789 aa 88.3 kDa	No	0
SPECC1L-003 ENSP00000414354 ENST00000440893	C9JLY8 [Direct mapping] Cytospin-A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		175 aa 18.9 kDa	No	0
SPECC1L-006 ENSP00000439633 ENST00000541492	Q69YQ0 [Direct mapping] Cytospin-A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005921 [gap junction] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0051301 [cell division] Show all	1078 aa 120.1 kDa	No	0
SPECC1L-201 ENSP00000393363 ENST00000437398	Q69YQ0 [Direct mapping] Cytospin-A Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0005921 [gap junction] GO:0007049 [cell cycle] GO:0007155 [cell adhesion] GO:0051301 [cell division] Show all	1117 aa 124.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.