Expression of PRODH in cancer - Summary - The Human Protein Atlas

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PRODH

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PRODH
Gene description	Proline dehydrogenase (oxidase) 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Cell line enriched (RPTEC TERT1)
HPA (normal tissue):	Tissue enhanced (small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA020361
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020361

GENE INFORMATION
Gene name	PRODH (HGNC Symbol)
Synonyms	HSPOX2, PIG6, PRODH1, PRODH2, TP53I6
Description	Proline dehydrogenase (oxidase) 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	18912777 - 18936553
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100033 (version 83.38)
Entrez gene	5625
UniProt	O43272 (UniProt - Evidence at protein level)
neXtProt	NX_O43272
Antibodypedia	PRODH antibodies

PROTEIN BROWSER

PRODH-001	PRODH-002	PRODH-004	PRODH-009	PRODH-010	PRODH-011	PRODH-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRODH-001 ENSP00000349577 ENST00000357068	O43272 [Direct mapping] Proline dehydrogenase 1, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004657 [proline dehydrogenase activity] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0006560 [proline metabolic process] GO:0006562 [proline catabolic process] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0010133 [proline catabolic process to glutamate] GO:0019470 [4-hydroxyproline catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding] Show all	600 aa 68 kDa	No	0
PRODH-002 ENSP00000334726 ENST00000334029	E7EQL6 [Direct mapping] Proline dehydrogenase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004657 [proline dehydrogenase activity] GO:0006562 [proline catabolic process] GO:0055114 [oxidation-reduction process] Show all	492 aa 56.3 kDa	No	0
PRODH-004 ENSP00000410805 ENST00000420436	E7EQL6 [Direct mapping] Proline dehydrogenase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004657 [proline dehydrogenase activity] GO:0006562 [proline catabolic process] GO:0055114 [oxidation-reduction process] Show all	492 aa 56.3 kDa	No	0
PRODH-009 ENSP00000413941 ENST00000457083	H7C3U9 [Direct mapping] Proline dehydrogenase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		164 aa 16.6 kDa	No	0
PRODH-010 ENSP00000396806 ENST00000450579	C9JIW4 [Direct mapping] Proline dehydrogenase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004657 [proline dehydrogenase activity] GO:0006562 [proline catabolic process] GO:0055114 [oxidation-reduction process] Show all	135 aa 15 kDa	No	0
PRODH-011 ENSP00000409742 ENST00000438924	H7C363 [Direct mapping] Proline dehydrogenase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004657 [proline dehydrogenase activity] GO:0006562 [proline catabolic process] GO:0055114 [oxidation-reduction process] Show all	185 aa 19.1 kDa	No	0
PRODH-201 ENSP00000480347 ENST00000610940	A0A087WWM6 [Direct mapping] Proline dehydrogenase 1, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004657 [proline dehydrogenase activity] GO:0006562 [proline catabolic process] GO:0055114 [oxidation-reduction process] Show all	600 aa 68 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.