Tissue expression of PRODH - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PRODH
Gene description	Proline dehydrogenase (oxidase) 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (small intestine)
GTEx:	Mixed
FANTOM5:	Tissue enhanced (caudate)

Protein evidence

Evidence at protein level

Protein expression

General cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA020361
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate)

GENE INFORMATION
Gene name	PRODH (HGNC Symbol)
Synonyms	HSPOX2, PIG6, PRODH1, PRODH2, TP53I6
Description	Proline dehydrogenase (oxidase) 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	18912777 - 18936553
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100033 (version 83.38)
Entrez gene	5625
UniProt	O43272 (UniProt - Evidence at protein level)
neXtProt	NX_O43272
Antibodypedia	PRODH antibodies

PROTEIN BROWSER

PRODH-001	PRODH-002	PRODH-004	PRODH-009	PRODH-010	PRODH-011	PRODH-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRODH-001 ENSP00000349577 ENST00000357068	O43272 [Direct mapping] Proline dehydrogenase 1, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004657 [proline dehydrogenase activity] GO:0005743 [mitochondrial inner membrane] GO:0005759 [mitochondrial matrix] GO:0006560 [proline metabolic process] GO:0006562 [proline catabolic process] GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress] GO:0010133 [proline catabolic process to glutamate] GO:0019470 [4-hydroxyproline catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0071949 [FAD binding] Show all	600 aa 68 kDa	No	0
PRODH-002 ENSP00000334726 ENST00000334029	E7EQL6 [Direct mapping] Proline dehydrogenase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004657 [proline dehydrogenase activity] GO:0006562 [proline catabolic process] GO:0055114 [oxidation-reduction process] Show all	492 aa 56.3 kDa	No	0
PRODH-004 ENSP00000410805 ENST00000420436	E7EQL6 [Direct mapping] Proline dehydrogenase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004657 [proline dehydrogenase activity] GO:0006562 [proline catabolic process] GO:0055114 [oxidation-reduction process] Show all	492 aa 56.3 kDa	No	0
PRODH-009 ENSP00000413941 ENST00000457083	H7C3U9 [Direct mapping] Proline dehydrogenase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		164 aa 16.6 kDa	No	0
PRODH-010 ENSP00000396806 ENST00000450579	C9JIW4 [Direct mapping] Proline dehydrogenase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004657 [proline dehydrogenase activity] GO:0006562 [proline catabolic process] GO:0055114 [oxidation-reduction process] Show all	135 aa 15 kDa	No	0
PRODH-011 ENSP00000409742 ENST00000438924	H7C363 [Direct mapping] Proline dehydrogenase 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004657 [proline dehydrogenase activity] GO:0006562 [proline catabolic process] GO:0055114 [oxidation-reduction process] Show all	185 aa 19.1 kDa	No	0
PRODH-201 ENSP00000480347 ENST00000610940	A0A087WWM6 [Direct mapping] Proline dehydrogenase 1, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004657 [proline dehydrogenase activity] GO:0006562 [proline catabolic process] GO:0055114 [oxidation-reduction process] Show all	600 aa 68 kDa	No	0