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SLC5A1

GENERAL INFORMATION

Gene name

 SLC5A1

Gene description

 Solute carrier family 5 (sodium/glucose cotransporter), member 1

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (CACO-2, RPMI-8226, SH-SY5Y)
HPA (normal tissue):Group enriched (duodenum, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective luminal membranous expression in small intestine and gallbladder.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA051805 , HPA055106 , CAB015467
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051805
HPA055106
CAB015467

GENE INFORMATION

Gene name

 SLC5A1 (HGNC Symbol)

Synonyms

 D22S675, NAGT, SGLT1

Description

 Solute carrier family 5 (sodium/glucose cotransporter), member 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 22

Cytoband

 q12.3

Chromosome location (bp)

 32043032 - 32113029

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100170 (version 83.38)

Entrez gene

 6523

UniProt

 P13866 (UniProt - Evidence at protein level)

neXtProt

 NX_P13866

Antibodypedia

 SLC5A1 antibodies

PROTEIN BROWSER
SLC5A1-001
SLC5A1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC5A1-001
ENSP00000266088
ENST00000266088
P13866 [Direct mapping]
Sodium/glucose cotransporter 1
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001656 [metanephros development]
GO:0005215 [transporter activity]
GO:0005355 [glucose transmembrane transporter activity]
GO:0005412 [glucose:sodium symporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0005911 [cell-cell junction]
GO:0005975 [carbohydrate metabolic process]
GO:0006810 [transport]
GO:0006814 [sodium ion transport]
GO:0008645 [hexose transport]
GO:0015758 [glucose transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0031526 [brush border membrane]
GO:0044281 [small molecule metabolic process]
GO:0050892 [intestinal absorption]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1904659 [glucose transmembrane transport]
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 664 aa
73.5 kDa 		No >9
SLC5A1-201
ENSP00000444898
ENST00000543737
P13866 [Direct mapping]
Sodium/glucose cotransporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005412 [glucose:sodium symporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006810 [transport]
GO:0006814 [sodium ion transport]
GO:0008645 [hexose transport]
GO:0015758 [glucose transport]
GO:0016020 [membrane]
GO:0044281 [small molecule metabolic process]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1904659 [glucose transmembrane transport]
Show all
 537 aa
60.1 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.