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FBXO7

GENERAL INFORMATION

Gene name

 FBXO7

Gene description

 F-box protein 7

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA032114 , CAB034296
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and colorectal cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA032114
CAB034296

GENE INFORMATION

Gene name

 FBXO7 (HGNC Symbol)

Synonyms

 Fbx, FBX7, PARK15

Description

 F-box protein 7 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it may play a role in regulation of hematopoiesis. Alternatively spliced transcript variants of this gene have been identified with the full-length natures of only some variants being determined. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q12.3

Chromosome location (bp)

 32474676 - 32498829

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100225 (version 83.38)

Entrez gene

 25793

UniProt

 Q9Y3I1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y3I1

Antibodypedia

 FBXO7 antibodies

PROTEIN BROWSER
FBXO7-001
FBXO7-002
FBXO7-006
FBXO7-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FBXO7-001
ENSP00000266087
ENST00000266087
Q9Y3I1 [Direct mapping]
F-box only protein 7
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000151 [ubiquitin ligase complex]
GO:0000422 [mitophagy]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006626 [protein targeting to mitochondrion]
GO:0016567 [protein ubiquitination]
GO:0019901 [protein kinase binding]
GO:0031647 [regulation of protein stability]
GO:0043234 [protein complex]
GO:0045620 [negative regulation of lymphocyte differentiation]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
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 522 aa
58.5 kDa 		No 0
FBXO7-002
ENSP00000380571
ENST00000397426
Q9Y3I1 [Direct mapping]
F-box only protein 7
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000422 [mitophagy]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006626 [protein targeting to mitochondrion]
GO:0016567 [protein ubiquitination]
GO:0031647 [regulation of protein stability]
GO:0043234 [protein complex]
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 408 aa
45.8 kDa 		No 0
FBXO7-006
ENSP00000388547
ENST00000452138
Q9Y3I1 [Direct mapping]
F-box only protein 7
Show all
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151 [ubiquitin ligase complex]
GO:0000422 [mitophagy]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006626 [protein targeting to mitochondrion]
GO:0016567 [protein ubiquitination]
GO:0031647 [regulation of protein stability]
GO:0043234 [protein complex]
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 443 aa
49.4 kDa 		No 0
FBXO7-007
ENSP00000404388
ENST00000444207
A2A282 [Direct mapping]
F-box only protein 7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 54 aa
5.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.