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TIMP3

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GENERAL INFORMATION

Gene name

 TIMP3

Gene description

 TIMP metallopeptidase inhibitor 3

Protein class

 Cancer-related genes
Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (BJ, WM-115, BJ hTERT+)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ, WM-115, BJ hTERT+)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 TIMP3 (HGNC Symbol)

Synonyms

 SFD

Description

 TIMP metallopeptidase inhibitor 3 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q12.3

Chromosome location (bp)

 32801701 - 32863043

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100234 (version 83.38)

Entrez gene

 7078

UniProt

 P35625 (UniProt - Evidence at protein level)

neXtProt

 NX_P35625

Antibodypedia

 TIMP3 antibodies

PROTEIN BROWSER
TIMP3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TIMP3-001
ENSP00000266085
ENST00000266085
P35625 [Direct mapping]
Metalloproteinase inhibitor 3
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007417 [central nervous system development]
GO:0007568 [aging]
GO:0007601 [visual perception]
GO:0008191 [metalloendopeptidase inhibitor activity]
GO:0009612 [response to mechanical stimulus]
GO:0009725 [response to hormone]
GO:0010033 [response to organic substance]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0014070 [response to organic cyclic compound]
GO:0031012 [extracellular matrix]
GO:0034097 [response to cytokine]
GO:0042246 [tissue regeneration]
GO:0043200 [response to amino acid]
GO:0043627 [response to estrogen]
GO:0045861 [negative regulation of proteolysis]
GO:0046872 [metal ion binding]
GO:0048553 [negative regulation of metalloenzyme activity]
GO:0051045 [negative regulation of membrane protein ectodomain proteolysis]
GO:0051593 [response to folic acid]
GO:0070062 [extracellular exosome]
GO:0071310 [cellular response to organic substance]
Show all
 211 aa
24.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.