Tissue expression of TIMP3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TIMP3
Gene description	TIMP metallopeptidase inhibitor 3
Protein class	Cancer-related genes Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (placenta)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TIMP3 (HGNC Symbol)
Synonyms	SFD
Description	TIMP metallopeptidase inhibitor 3 (HGNC Symbol)
Entrez gene summary	This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q12.3
Chromosome location (bp)	32801701 - 32863043
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000100234 (version 83.38)
Entrez gene	7078
UniProt	P35625 (UniProt - Evidence at protein level)
neXtProt	NX_P35625
Antibodypedia	TIMP3 antibodies

PROTEIN BROWSER

TIMP3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TIMP3-001 ENSP00000266085 ENST00000266085	P35625 [Direct mapping] Metalloproteinase inhibitor 3 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005604 [basement membrane] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007417 [central nervous system development] GO:0007568 [aging] GO:0007601 [visual perception] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0009612 [response to mechanical stimulus] GO:0009725 [response to hormone] GO:0010033 [response to organic substance] GO:0010951 [negative regulation of endopeptidase activity] GO:0014070 [response to organic cyclic compound] GO:0031012 [extracellular matrix] GO:0034097 [response to cytokine] GO:0042246 [tissue regeneration] GO:0043200 [response to amino acid] GO:0043627 [response to estrogen] GO:0045861 [negative regulation of proteolysis] GO:0046872 [metal ion binding] GO:0048553 [negative regulation of metalloenzyme activity] GO:0051045 [negative regulation of membrane protein ectodomain proteolysis] GO:0051593 [response to folic acid] GO:0070062 [extracellular exosome] GO:0071310 [cellular response to organic substance] Show all	211 aa 24.1 kDa	Yes	0