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PACSIN2

GENERAL INFORMATION

Gene name

 PACSIN2

Gene description

 Protein kinase C and casein kinase substrate in neurons 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA049854 , HPA056520
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049854
HPA056520

GENE INFORMATION

Gene name

 PACSIN2 (HGNC Symbol)

Synonyms

 SDPII

Description

 Protein kinase C and casein kinase substrate in neurons 2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Chromosome

 22

Cytoband

 q13.2

Chromosome location (bp)

 42835412 - 43015145

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100266 (version 83.38)

Entrez gene

 11252

UniProt

 Q9UNF0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNF0

Antibodypedia

 PACSIN2 antibodies

PROTEIN BROWSER
PACSIN2-001
PACSIN2-003
PACSIN2-004
PACSIN2-005
PACSIN2-006
PACSIN2-007
PACSIN2-008
PACSIN2-009
PACSIN2-016
PACSIN2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PACSIN2-001
ENSP00000263246
ENST00000263246
Q9UNF0 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005901 [caveola]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0008289 [lipid binding]
GO:0019898 [extrinsic component of membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030100 [regulation of endocytosis]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031988 [membrane-bounded vesicle]
GO:0032587 [ruffle membrane]
GO:0036010 [protein localization to endosome]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045806 [negative regulation of endocytosis]
GO:0048858 [cell projection morphogenesis]
GO:0055038 [recycling endosome membrane]
GO:0070062 [extracellular exosome]
GO:0070300 [phosphatidic acid binding]
GO:0070836 [caveola assembly]
GO:0072584 [caveolin-mediated endocytosis]
GO:0097320 [membrane tubulation]
Show all
 486 aa
55.7 kDa 		No 0
PACSIN2-003
ENSP00000385952
ENST00000407585
Q9UNF0 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 2
Q6FIA3 [Target identity:100%; Query identity:100%]
PACSIN2 protein
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005856 [cytoskeleton]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030100 [regulation of endocytosis]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031988 [membrane-bounded vesicle]
GO:0032587 [ruffle membrane]
GO:0036010 [protein localization to endosome]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048858 [cell projection morphogenesis]
GO:0055038 [recycling endosome membrane]
GO:0070062 [extracellular exosome]
GO:0070300 [phosphatidic acid binding]
GO:0070836 [caveola assembly]
GO:0072584 [caveolin-mediated endocytosis]
GO:0097320 [membrane tubulation]
Show all
 445 aa
51.4 kDa 		No 0
PACSIN2-004
ENSP00000385040
ENST00000402229
Q9UNF0 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005856 [cytoskeleton]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030100 [regulation of endocytosis]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031988 [membrane-bounded vesicle]
GO:0032587 [ruffle membrane]
GO:0036010 [protein localization to endosome]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048858 [cell projection morphogenesis]
GO:0055038 [recycling endosome membrane]
GO:0070062 [extracellular exosome]
GO:0070300 [phosphatidic acid binding]
GO:0070836 [caveola assembly]
GO:0072584 [caveolin-mediated endocytosis]
GO:0097320 [membrane tubulation]
Show all
 486 aa
55.7 kDa 		No 0
PACSIN2-005
ENSP00000385372
ENST00000403744
Q9UNF0 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005856 [cytoskeleton]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030100 [regulation of endocytosis]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031988 [membrane-bounded vesicle]
GO:0032587 [ruffle membrane]
GO:0036010 [protein localization to endosome]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048858 [cell projection morphogenesis]
GO:0055038 [recycling endosome membrane]
GO:0070062 [extracellular exosome]
GO:0070300 [phosphatidic acid binding]
GO:0070836 [caveola assembly]
GO:0072584 [caveolin-mediated endocytosis]
GO:0097320 [membrane tubulation]
Show all
 486 aa
55.7 kDa 		No 0
PACSIN2-006
ENSP00000403435
ENST00000422336
B0QYG7 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0008092 [cytoskeletal protein binding]
GO:0030100 [regulation of endocytosis]
GO:0031988 [membrane-bounded vesicle]
Show all
 152 aa
17.9 kDa 		No 0
PACSIN2-007
ENSP00000398573
ENST00000453643
B0QYG8 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0008092 [cytoskeletal protein binding]
GO:0030100 [regulation of endocytosis]
GO:0031988 [membrane-bounded vesicle]
Show all
 155 aa
18.2 kDa 		No 0
PACSIN2-008
ENSP00000399953
ENST00000453079
B0QYG9 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0008092 [cytoskeletal protein binding]
GO:0030100 [regulation of endocytosis]
GO:0031988 [membrane-bounded vesicle]
Show all
 33 aa
3.8 kDa 		No 0
PACSIN2-009
ENSP00000396816
ENST00000418133
B0QYG7 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0008092 [cytoskeletal protein binding]
GO:0030100 [regulation of endocytosis]
GO:0031988 [membrane-bounded vesicle]
Show all
 152 aa
17.9 kDa 		No 0
PACSIN2-016
ENSP00000489297
ENST00000634914
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 451 aa
51.8 kDa 		No 0
PACSIN2-201
ENSP00000338379
ENST00000337959
Q9UNF0 [Direct mapping]
Protein kinase C and casein kinase substrate in neurons protein 2
Q6FIA3 [Target identity:100%; Query identity:100%]
PACSIN2 protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005856 [cytoskeleton]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0008092 [cytoskeletal protein binding]
GO:0019898 [extrinsic component of membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030100 [regulation of endocytosis]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031988 [membrane-bounded vesicle]
GO:0032587 [ruffle membrane]
GO:0036010 [protein localization to endosome]
GO:0042802 [identical protein binding]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048858 [cell projection morphogenesis]
GO:0055038 [recycling endosome membrane]
GO:0070062 [extracellular exosome]
GO:0070300 [phosphatidic acid binding]
GO:0070836 [caveola assembly]
GO:0072584 [caveolin-mediated endocytosis]
GO:0097320 [membrane tubulation]
Show all
 445 aa
51.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.